Professeur jobs in Mexico

Organisation/Company: Université Marie et Louis Pasteur

Research Field: Medical sciences » Cancer research

Researcher Profile: Established Researcher (R3)

Positions: Other Positions

Country: France

Application Deadline: 2 Sep 2025 - 00:00 (Europe/Paris)

Type of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 1 Dec 2025

Is the job funded through the EU Research Framework Programme?: Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure?: No

Summary of the scientific project:

In cancer as well as chronic infections, T cells are exposed to persistent antigens and acquire a dysfunctional gene expression program which includes high expression of the inhibitory receptor Programmed Cell Death-1 (PD-1). PD-1 targeted therapies elicit clinical responses in different cancer types, but response rates are rarely above 20%. Positive outcomes have been associated with CD8 T cell responses and the heterogeneity of the tumor immune infiltrate might account for at least part of the variability in responses. Among PD-1+CD8 T cells, progenitor exhausted T cells (Tpex, TCF-1+PD-1+CD8 T cells) play a central role in the proliferation burst following PD-1 therapy. In cancer patients, the presence of Tpex in tumors has been associated with response to PD-1 therapy. Tpex need to differentiate into effector-like cells to reduce tumor burden. Recent findings highlight a central role for CD4 help in both supporting CD8 T cell cytotoxicity and success of PD-1 targeted therapy. However, molecular and cellular mechanisms underlying CD4 and CD8 crosstalk during persistent antigen stimulation remain to be determined. The candidate will investigate how CD4 help (cytokines, chemokines, costimulation signaling, DC licensing) supports effective differentiation of CD8 T cells during antigen persistence. These findings will be critical for the design of new combination therapies with PD-1 blockade to achieve long-term benefit.

It is expected that the recruited researcher will rapidly become a group leader in the GAD team. The candidate should demonstrate the ability to supervise Ph.D. students, post-doctoral fellows, and technical support staff. She/he should have the capacity to obtain competitive funding to manage her/his group.

Successful candidates are chosen by a selection commission composed of six to ten members, the majority of whom are specialists in the fields of research concerned. The commission carries out an initial examination of the applications, focused in particular on candidate experience and skills relative to the research and teaching project presented above. A shortlist of candidates is then selected for interview. Only candidates selected by the selection committee on the basis of their applications will be invited to interview.

The interviews are followed by a deliberation during which the selection commission will discuss the quality, originality, and, where appropriate, the interdisciplinarity of the research and teaching projects presented by the candidates, their motivation, and their scientific and teaching supervision capacity. The candidates selected at the end of the selection process will be offered a researcher contract, following approval from the President and CEO of Inserm.

Summary of the teaching project:

The candidate will be involved in the training/research link by supervising doctoral students and setting up a tutoring program as part of the graduates school. The CPJ will organize and promote international scientific seminars open to I3C and SCM master degree students.

CPJ will promote exchanges with foreign laboratories so that our students can go to international laboratories to further their training. As part of these exchanges, CPJ can offer training in areas of expertise to foreign partner institutions.

- Research: number of high-impact scientific publications, number of international publications and publications with international collaborations; number of research grants (ANR JCJC, PLBio, ERC…); invited speaker for international congress.

- Teaching: student supervision (PhD student, master's); training of young researchers (Post-doc); habilitation to supervise research.

- Open Science, Science and society: number of publications in high quality open access journals; communications within national and European immunology and immuno-oncology networks (SFI, FITC, SITC…); communications for the general public (press, social networks, media…); organization of local scientific meetings.

These indicators will be reviewed during an individual annual interview.

E-mail: chaires-professeur-junior@inserm.fr

Research Field: Medical sciences

Education Level: PhD or equivalent

Skills/Qualifications:

Research Fields: Immunology, Oncology (Medical sciences)

Corresponding specialized INSERM scientific commissions (CSS):

• CSS 2 - Oncology, genetic diseases

T cell exhaustion, progenitor PD1+ CD8 T cells, CD4 T cell, cancer immunotherapy

The candidate must be able to obtain competitive funding to manage his group.

Salary: 3,500€ - 5,000€ according to research experience

Additional comments: It is imperative to contact the laboratory corresponding to the Chair you have applied for in order to build the project with them.