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Organisation / Company UNIVERSIDAD CATÓLICA DE MURCIA - FUNDACIÓN UNIVERSITARIA SAN ANTONIO DE MURCIA Research Field Chemistry » Analytical chemistry Researcher Profile First Stage Researcher (R1) Positions Master Positions Country Spain Application Deadline 31 Jul 2025 - 00 : 00 (Europe / Madrid) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Project Background : Close2Cell The Close2Cell project addresses the growing need for innovative analytical tools that enable real-time, continuous single-cell analysis of ions and proteins. This project proposes a disruptive sensing approach based on label- free potentiometric nanosensors capable of detecting potassium, sodium, calcium, pH, chloride, bicarbonate, and Interleukin-6 (IL-6). For IL-6 detection, the approach uniquely leverages endogenous potassium levels within cells as an indirect biomarker , using selective protein– antibody interactions to perturb potassium ion transfer across a selective membrane. This mechanism is integrated into the potentiometric sensor for indirect IL-6 quantification. The project explores multiple innovation strategies to design and validate versatile potentiometric nanoprobes with high analytical performance tailored for single-cell applications. These sensors will be tested in artificial media, cytosolic samples, and cell- based systems using various cell lines under stimulation (e.g., pharmaceutical exposure). This approach is minimally invasive, cost-effective, and aligned with sustainable innovation in health monitoring. Close2Cell supports Sustainable Development Goals 3 and 10 , promoting Good Health and Well-Being and Reducing Inequalities. The outcomes are expected to contribute significantly to understanding cellular physiology and pathology, particularly in the context of the EU Mission : Cancer . Candidate Profile – Requirements We are seeking highly motivated and qualified candidates for a PhD fellowship at UCAM- SENS. Applicants must have :
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