lavori presso MD in località Italia

APPLICATION CLOSING DATE : 1st July 2025

Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers : Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

About the lab

The Coscia Group HT, part of the Human Technopole's Centre for Structural Biology, is dedicated to integrative structural biology of the thyroid signaling pathway. Our research aims to visualize thyroid processes, from the atomic level to organoids, to understand both healthy thyroid function and how it is altered in diseases such as auto-immune conditions, congenital hypothyroidism, and various thyroid cancers. Our long-term goal is to contribute to improved diagnosis and treatment strategies for major thyroid disorders. We are committed to fostering a collaborative and intellectually stimulating environment, pushing the boundaries of scientific discovery.

For more details on our work, please visit our group's page :

See previous work on the research topics of this call :

Key tasks and responsibilities

The successful candidate will play a crucial role in the Coscia Group HT, contributing to both experimental biochemical and structural investigations and computational modelling efforts. Responsibilities will include, but are not limited to :

Working on multiple projects at the same time, developing or automating new tools and research avenues for the laboratory, collaborating and assisting other members of the group.

Performing a range of biochemical experiments, including cloning, protein expression and purification, enzyme assays, binding studies

Preparing samples for and assisting with advanced biophysical characterization techniques (e.g., MST, BLI, DSF).

Preparing samples for SPA cryo-EM structural characterization.

Executing model building and computational modelling tasks, including building cryo-EM models, setting up and running Alpha Fold advanced predictions, molecular dynamics simulations, docking studies, and data analysis using relevant software packages.

Maintaining laboratory equipment, ensuring proper functionality and calibration.

Accurate electronic data recording, organization, and quantitative analysis of the data

Contributing to the preparation of scientific reports, presentations, and publications.

Adhering to laboratory safety protocols and best practices and guiding others to respect them

Being responsible for general lab management tasks (inventory, orders, communications with other lab managers and technicians) and providing regular reports to the group leader.

On the closing date for online applications, the candidate must fulfil all the following conditions :

BcS or Mcs in Biochemistry, Biophysics, Structural Biology, Chemistry, or a closely related field.

Demonstrated practical experience in standard biochemical laboratory techniques (e.g., cloning, protein expression, purification, spectrophotometry, biophysical characterisation of proteins).

Minimum of 5 years (Phd included) or equivalent experience in a technical or research role, with advanced responsibilities for seniors and 3 years for juniors.

Proficiency in English, both written and spoken.

Ability to work independently and as part of a team, with excellent organizational and problem-solving skills.

Preferred requirements

Previous experience with cloning, protein expression systems (e.g., E. coli , mammalian) and protein purification

Experience with advanced biophysical techniques such as MST, BLI, DSF and relative data analysis

Familiarity with SPA Cryo-EM workflows (preparation of EM grids, data collection, image processing) and modelling computational tools (e.g., MD, model building)

Organizational and social skills :

Communication, team building and problem-solving skills.

Ability to work independently and as part of a team, with excellent organizational and problem-solving skills.

Highly organised and meticulous work attitude.

Application Instructions

To apply, please send the following :

a CV.

a motivation letter in English relating your track record to the specifics of the call.

names and contacts of 2 referees.

Why Human Technopole

HT seeksscientific excellence, we recruit the best scientific talents through international, open calls.

Our working environment isinternational,friendlyandinclusive. Our scientistswork together across disciplineson research topics of biomedical relevance,leveraging synergiesbetween their diverse skillsets and methodological approaches.

We believe thathighly diverse teams yield the best and most innovative results.

We engage inoutward-facing scientific activitiesaimed at benefiting the national and internationalresearch community.Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.

Work-life balance provisions.

Italian language training for foreigners.

Parental leave up to 1 year and other support for new parents.

Counseling.

Support for relocation.

Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits.

Special consideration will be given to candidates who are part of the protected categories list, according to L. 68 / 99.

Number of positions offered : 1

Contract offered : CCNL Chimico Farmaceutico, Fixed-term 3 years - Employee Level

Salary range : up to 40K, depending on the seniority of the candidate.

Tax benefits where applicable.

The position is based inMilan.

The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favor of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and / or obstructive circumstances”.

J-18808-Ljbffr