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Organisation/Company Inserm Department Délégation régionale nord ouest Research Field Medical sciences » Health sciences Researcher Profile Established Researcher (R3) Country France Application Deadline 31 Dec 2025 - 00:00 (Europe/Paris) Type of Contract Permanent Job Status Full-time Hours Per Week 38.30 Offer Starting Date 1 Apr 2024 Is the job funded through the EU Research Framework Programme? European Union / Next Generation EU Is the Job related to staff position within a Research Infrastructure? No

Offer for mobility: Researcher in the Laboratory :

Molecular and cellular physiopathology of cardio-metabolic diseases

Function: Search Function

Corps: Director of Research, Research Officer.

The INSERM UMR1167 RID-AGE Unit, led by Professor Philippe Amouyel, aims to analyze, explore and understand the evolutions and determinants of the main chronic diseases (cardiovascular, metabolic and neurodegenerative) linked to ageing in order to offer new perspectives for prevention and treatment, paving the way for personalised medicine and longer life expectancy without disability.

Team 1 focuses on public health and the epidemiology of aging-related diseases.

Team 2 researches the molecular determinants of cardiovascular diseases (type 2 diabetes, heart remodeling, heart failure) and team 3 those of Alzheimer’s disease and related diseases.

Team 4 allows to broaden these approaches by the structural analysis of molecules.

Team 5 is interested in the links between aging and chronic inflammation. The unit coordinates the DISTALZ laboratory of excellence dedicated to the development of innovative strategies for a transdisciplinary approach to Alzheimer’s disease.

The fundamental mission of RID-AGE will be to achieve major breakthroughs both in the better understanding of these diseases and in their diagnosis and therapeutic treatments.

Over the past ten years, this unit has made significant advances in understanding diseases related to aging, paving the way for concrete preventive procedures and the discovery of new drugs. It has gained international recognition with a wide openness to the general public to help us live better, longer.

In order to develop and strengthen this excellent research activity, the CardioDiab team led by Dr Jean-Sébastien Annicotte proposes to welcome a researcher/a statutory researcher wishing to bring its expertise in the field of cardiovascular diseases and take advantage of the exceptional environment of RID-AGE and the campus of the Institut Pasteur de Lille to develop its projects.

E-mail jean-sebastien.annicotte@inserm.fr

Research Field Medical sciences » Health sciences Education Level PhD or equivalent

Skills/Qualifications

• Research activity in the field of pathophysiology of cardio-metabolic diseases.
• Develop or participate in a research project concerning cellular plasticity in the pathogenesis of metabolic diseases (type 2 diabetes, obesity) and/or cardiovascular disease (heart failure).
• Coaching of permanent and non-permanent team members, in association with the managers already present.
• Scientific animation of the team, the Unit and the Institute.
• Knowledge: Cell biology, physiology, pathophysiology, cardiovascular diseases, stem cells, use of high-throughput analysis tool.
• Expertise/Methodology: Cell biology, animal experimentation (holder habilitation level 1), molecular biology, multi-omics approaches.
• Skills: Teamwork, supervision of students and engineers/technicians.
• Training/Experience Required: PhD in Biology.

Specificity/ Constraints of the position: We wish to welcome a researcher. He has worked in a unit internationally recognized for its research on cardio-metabolic diseases. The researcher will benefit from the infrastructure and platforms of the Institut Pasteur in Lille and the University of Lille (EOPS pet store, next generation sequencing, O-link, immunophenotyping, imaging, cytometry, etc.) and the dynamics of the unit of attachment.