Computational biologist (H/F)

Université PSL; Orsay; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

A leading research institution in Orsay seeks a computational biologist to lead bioinformatic analyses for cancer research. Responsibilities include developing robust data processing pipelines and collaborating with international partners. Candidates should have a PhD in Bioinformatics or related field and a strong background in molecular biology. Proficiency in R and Python is essential. Full-time CDD contract with benefits including collective catering and transport reimbursement.

Prestations

Collective catering

Transportation reimbursement

Supplementary health insurance

Qualifications

• PhD (or MSc with significant experience) in Bioinformatics, Computational Biology, or related field.
• Solid background in molecular biology and experience in interdisciplinary environments.
• Proficiency in R, Python, and Bash.

Responsabilités

• Design, implement, and maintain pipelines for data processing.
• Perform clustering and trajectory inference.
• Work closely with radiation biologists and collaborate internationally.

Connaissances

Data processing

Pipeline development

Single cell analysis

Statistical integration

Scientific communication

Formation

PhD or MSc in Bioinformatics

Outils

R

Python

Bash

Description du poste

About us

The Curie Institute Research Center

The “Institut Curie” is a major player in the research and fight against cancer. It consists of a hospital and a Research Center. Institut Curie is a major player in cancer research and the fight against cancer. It consists of a hospital and a research center with more than 1000 employees with a strong international representation. The objective of the Institut Curie Research Center is to develop fundamental research and use the knowledge generated to improve the diagnosis, prognosis and therapeutics of cancers within the continuum between fundamental research and innovation for the benefit of patients.

Mission

Job description

Laboratory

The "Repair, Radiation and Innovative Anti-Cancer Therapies" team (U1021 / UMR3347 / Université Paris-Saclay) investigates the changes at the cellular and molecular level induced by radiotherapy in the lung (Curras-Alonso et al. Nature Communications 2023). Using cutting-edge single cell technologies (scRNAseq, spatial transcriptomic), current projects aim at identifying key mechanisms underlying effects of radiotherapy on healthy tissue and tumor. To achieve these goals, the team is looking for a computational biologist to lead the bioinformatic analysis and integration of the different sets of data (scRNAseq, spatial transcriptomic, lipidomic). This position will benefit from the expertise of the lab as well as close interactions with radiation biologists of the team and external collaborations.

Missions

• Data processing and Pipeline development: Design, implement, and maintain robust pipelines for processing scRNA-seq and spatial analysis including data quality control, normalization and batch effect correction.
• Single cell and Spatial transcriptomic analysis: Perform clustering, cell-type annotation, trajectory inference, cell-cell communication.
• Data integration: Apply statistical and machine learning approaches to integrate single cell and spatial analysis in order to identify molecular signatures and pathways underlying radiation-induced effects.
• Collaboration: Work in close interaction with radiation biologists and collaborate with international partners through interdisciplinary projects.
• Scientific communication: Present results in lab meetings, seminars, and international conferences as well as contribute to manuscripts, grant applications.

Profile

Desired profile

Education and Skills

• PhD (or MSc with significant experience) in Bioinformatics, Computational Biology, Biostatistics, Systems Biology, or related field.
• Solid background in molecular biology and / or single cell approaches is a strong plus.
• Experience in interdisciplinary environments (biology + computation) highly valued.
• Proficiency in R (Bioconductor, tidyverse), Python (NumPy, Pandas, scikit-learn) and Bash
• Previous experiences in single cell RNA-seq (Seurat, Scanpy) and / or spatial analysis (Giotto, Squidpy) would be a plus.

Required qualities

• Rigor, autonomy, and problem-solving mindset.
• Strong organizational skills and ability to work independently.
• Team spirit, openness to international collaboration
• Good written and oral communication skills (French and / or English desired).

All our opportunities are open to people with disabilities.

Contract information

• Type of contract: CDD
• Starting date: 01 / 12 / 2025
• Duration: 18 months that can be extended
• Working time: full time
• Remuneration: according to the current grids
• Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Orsay

Contact

Please send your CV, letter of motivation and 2 references, to

Publication date: 09 / 09 / 2025

Deadline for application: 15 / 11 / 2025

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf