Quality Control jobs in Singapore

• Bioreactor Operations
• Media and Reagent Preparation
• Cell Banking & Subculturing

Role Summary

We are looking for a motivated Biotechnologist, you will execute routine and critical manufacturing operations within the Cell Culture (upstream) area, ensuring consistent production of clinical and/or commercial biologics. You will operate and maintain bioreactors and related equipment in compliance with GMP guidelines and SOPs, contributing to process reliability and product quality.

Key Responsibilities

• Bioreactor Operations:
  • Prepare, set up, and operate single-use and stainless-steel bioreactors (from 50 L to 2 000 L scale).
  • Monitor and adjust culture parameters (pH, DO, temperature, agitation) to maintain optimal cell growth.
• Media and Reagent Preparation:
  • Formulate and sterilize culture media, feed solutions, and buffers.
  • Perform buffer exchanges and feed additions according to batch protocols.
• Cell Banking & Subculturing:
  • Thaw, expand, and maintain working and master cell banks under sterile conditions.
  • Conduct viability and sterility checks (trypan blue exclusion, microscopic inspection).
• Sampling & In-Process Testing:
  • Collect and process samples for cell density, viability, metabolite, and metabolomic analyses.
  • Document results accurately in electronic batch records.
• Equipment Cleaning & Sterilization:
  • Execute CIP/SIP procedures on reactors, tubing, and ancillary equipment.
  • Maintain cleanroom attire discipline and adhere to gowning/ungowning protocols.
• Documentation & Compliance:
  • Follow SOPs, batch records, and deviation/incident reporting processes.
  • Participate in periodic audits, investigations, and continuous improvement initiatives.
• Cross-Functional Support:
  • Collaborate with Purification, Quality, and Engineering teams to troubleshoot process deviations.
  • Assist in scale-up activities and technology transfer to downstream processes.

Must-Have Qualifications

• Studied in Biotechnology, Biochemical Engineering, Microbiology, or related life-science field.
• Minimally internship experience of hands-on experience in mammalian cell culture or microbial fermentation at production scale.
• Familiarity with GMP, GCP, and GDP standards in a biologics manufacturing environment.
• Strong aseptic technique and cleanroom behavior.
• Experience with single-use bioreactor systems and associated control software (e.g., Sartorius Biostat, Ambr).
• Proficient in documentation.

We regret to inform that only shortlisted candidates will be notified.

EA Registration No:R22109832,LEE YAO HONG MALCOLM

Allegis Group Singapore Pte Ltd, Company Reg No. 200909448N, EA License No. 10C4544