Biologie à France

The position holder will carry out these in vitro chelation studies on synthetic media mimicking different compartments of the gastrointestinal tract (stomach, small intestine, colon) by varying the pH (2; 4.5 and 8), in the presence or absence of cations (mimicking the alimentary bolus) that can interfere with the chelation of the target isotopes and under thermostated conditions (37°C), to get as close as possible to physiological conditions. The principle of the tests is based on the evaluation of the chelation rate of the isotopes as a function of the quantity of polymer by the mean of ultrafiltration experiments : after an incubation period of MEX-CD1 with the isotopes, the mixture is ultrafiltered through a semi-permeable membrane. Depending on the nature of the radiation and the activities used, the analysis of the isotopes in the different fractions (filtrate and concentrate) will be carried out by inductively coupled plasma mass spectrometry (ICP-MS), alpha or gamma spectrometry.

• Performing in vitro chelation studies of the radioisotopes (uranium, plutonium, thorium, americium, neptunium, and polonium) or stable isotopes (cesium, cobalt and strontium) by the functionalized polymer MEX-CD1 using the ultrafiltration technique;
• Analyzing the radionuclides and metal ions in the different mediums and samples using analytical techniques (ICP-MS, alpha or gamma spectrometry);
• Analyzing the results of experiments and writing articles for publication in peer-reviewed journals, as well as research reports for internal or external purpose;
• Preparing and presenting talks and poster presentations at internal and external seminars and meetings when requested and approved;

• PhD degree in physical chemistry, coordination chemistry, biology, chemistry or a relevant discipline from a recognized university;
• Comprehensive background and experience in one or more of the following areas : metal complexation and chelation, coordination chemistry, analytical chemistry, biochemistry or radiochemistry;
• Demonstrated ability to publish research results as a lead author in peer-reviewed scientific literature;
• Effective communication skills to present results of research as demonstrated by a record of conference or other oral presentations in English;
• Demonstrated high organisation skills, interpersonal skills and ability to work as a part of a multidisciplinary and dynamic team;

Diversity is one of the components of IASNR's CSR, HR and Quality of Working Life policies. We give equal consideration to all applications, without discrimination, to include all talents. Whatever the differences, we aim to attract, integrate and retain our candidates and employees within an inclusive working environment. ASNR pursues an active policy in favor of equal opportunities in the workplace and the employment of disabled people. If you have a disability, please let us know if you have any specific needs that we can take into account.

Europe, France, Ile-de-France, Hauts-de-Seine