Project “In vitro study of the chelation of radionuclides by a functionalized polymer (PsD 25-0[...]

IRSN; Nanterre; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Une organisation scientifique en Île-de-France recherche un titulaire de poste pour effectuer des études de chélation in vitro sur des isotopes dans des conditions simulant le tractus gastro-intestinal. Le candidat doit détenir un doctorat en chimie, posséder de solides compétences en chimie analytique et être capable de communiquer les résultats de recherche. Ce poste comprend la rédaction de publications scientifiques et la présentation lors de séminaires.

Qualifications

• Diplôme de doctorat requis.
• Expérience en chimie analytique et complexe.
• Capacité à publier des résultats de recherche comme auteur principal.
• Compétences en communication en anglais exigées.
• Capacité à travailler dans une équipe multidisciplinaire.

Responsabilités

• Réaliser des études de chélation de radio-isotopes.
• Analyser des radionucléides et des ions métalliques avec des techniques analytiques.
• Rédiger des articles scientifiques pour des revues à comité de lecture.
• Préparer et présenter des communications lors de séminaires.

Connaissances

Chimie analytique

Chimie de coordination

Complexation des métaux

Rédaction de publications scientifiques

Compétences en communication

Travail en équipe

Formation

Doctorat en chimie physique, chimie de coordination, biologie ou discipline pertinente

Outils

Spectrométrie de masse couplée à plasma

Spectrométrie alpha ou gamma

Description du poste

Mission

The position holder will carry out these in vitro chelation studies on synthetic media mimicking different compartments of the gastrointestinal tract (stomach, small intestine, colon) by varying the pH (2; 4.5 and 8), in the presence or absence of cations (mimicking the alimentary bolus) that can interfere with the chelation of the target isotopes and under thermostated conditions (37°C), to get as close as possible to physiological conditions. The principle of the tests is based on the evaluation of the chelation rate of the isotopes as a function of the quantity of polymer by the mean of ultrafiltration experiments : after an incubation period of MEX-CD1 with the isotopes, the mixture is ultrafiltered through a semi-permeable membrane. Depending on the nature of the radiation and the activities used, the analysis of the isotopes in the different fractions (filtrate and concentrate) will be carried out by inductively coupled plasma mass spectrometry (ICP-MS), alpha or gamma spectrometry.

This includes, but is not limited to :

• Performing in vitro chelation studies of the radioisotopes (uranium, plutonium, thorium, americium, neptunium, and polonium) or stable isotopes (cesium, cobalt and strontium) by the functionalized polymer MEX-CD1 using the ultrafiltration technique;
• Analyzing the radionuclides and metal ions in the different mediums and samples using analytical techniques (ICP-MS, alpha or gamma spectrometry);
• Analyzing the results of experiments and writing articles for publication in peer-reviewed journals, as well as research reports for internal or external purpose;
• Preparing and presenting talks and poster presentations at internal and external seminars and meetings when requested and approved;

Profil recherché

• PhD degree in physical chemistry, coordination chemistry, biology, chemistry or a relevant discipline from a recognized university;
• Comprehensive background and experience in one or more of the following areas : metal complexation and chelation, coordination chemistry, analytical chemistry, biochemistry or radiochemistry;
• Demonstrated ability to publish research results as a lead author in peer-reviewed scientific literature;
• Effective communication skills to present results of research as demonstrated by a record of conference or other oral presentations in English;
• Demonstrated high organisation skills, interpersonal skills and ability to work as a part of a multidisciplinary and dynamic team;

Télétravail

Régulier Informations complémentaires / avantages

Occasional trips

Diversité

Diversity is one of the components of IASNR's CSR, HR and Quality of Working Life policies. We give equal consideration to all applications, without discrimination, to include all talents. Whatever the differences, we aim to attract, integrate and retain our candidates and employees within an inclusive working environment. ASNR pursues an active policy in favor of equal opportunities in the workplace and the employment of disabled people. If you have a disability, please let us know if you have any specific needs that we can take into account.

Localisation du poste

Europe, France, Ile-de-France, Hauts-de-Seine