M/F Postdoc position in Molecular & Cellular Neuroscience

CNRS; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

A renowned research institute in Paris is seeking a highly motivated postdoctoral scientist to explore the dynamics of glycine, D-serine, and zinc in NMDA receptor modulation and synaptic plasticity. The role requires strong expertise in cellular electrophysiology and a keen interest in neurotransmission. You will utilize innovative tools and methodologies to tackle complex biological questions, collaborating with world-class researchers in a stimulating environment. This position offers an opportunity for impactful research in a leading European life science institute.

Qualifications

• Solid expertise in cellular electrophysiology required.
• Experience in cellular imaging is preferred.
• Strong interest in neurotransmission and synaptic biology.

Responsabilités

• Investigate the dynamics and role of glycine, D-serine, and zinc in brain function.
• Develop and utilize original tools for molecular and genetic analysis.
• Engage in advanced methodologies across various biological techniques.

Connaissances

Cellular electrophysiology

Cellular imaging

Neurotransmission

Synaptic biology

Formation

PhD in a relevant field

Description du poste

Organisation/Company CNRS Department Institut de biologie de l'Ecole Normale Supérieure Research Field Neurosciences Biological sciences Researcher Profile Recognised Researcher (R2) Application Deadline 2 Feb 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Mar 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We seek to hire a highly motivated postdoctoral scientist to investigate the dynamics and role of glycine, D-serine and zinc – three key endogenous modulators of NMDA receptors – in brain function and synaptic plasticity. The dynamics and rules of neuromodulation by these three atypical factors during synaptic activity and naturally occurring stimuli remain mostly elusive due to the lack of appropriate tools for their detection and manipulation. In this project, we propose to tackle these issues using original tools – both molecular (sensors) and genetic (transgenic mice) – developed by our laboratory and by collaborators from the ENS Chemistry Department. The project combines various advanced methodologies at the cross-road between cellular electrophysiology, chemical biology, molecular pharmacology, optogenetics and cellular imaging. It is part of recently awarded ANR funding and is to be developed in the team of Pierre Paoletti at the Institute of Biology of the Ecole Normale Supérieure (IBENS) in Paris.

We seek to hire a highly motivated postdoctoral scientist to investigate the dynamics and role of glycine, D-serine and zinc – three key endogenous modulators of NMDA receptors – in brain function and synaptic plasticity. The dynamics and rules of neuromodulation by these three atypical factors during synaptic activity and naturally occurring stimuli remain mostly elusive due to the lack of appropriate tools for their detection and manipulation. In this project, we propose to tackle these issues using original tools – both molecular (sensors) and genetic (transgenic mice) – developed by our laboratory and by collaborators from the ENS Chemistry Department. The project combines various advanced methodologies at the cross-road between cellular electrophysiology, chemical biology, molecular pharmacology, optogenetics and cellular imaging. It is part of recently awarded ANR funding and is to be developed in the team of Pierre Paoletti at the Institute of Biology of the Ecole Normale Supérieure (IBENS) in Paris.

The Paoletti team has worldwide recognition for its work on the structure and function of glutamate receptors, and the regulation of excitatory synapses.
IBENS is a leading European life science institute that gathers world-class researchers in Genetics & Genomics, Cell & Developmental biology, Evolution, and Neuroscience. It is located in the center of Paris and offers a highly stimulating environment, close to several other top research institutions within PSL University (Institut Curie, Collège de France, ESPCI…).

The candidate should have a solid expertise in cellular electrophysiology and, preferably, also in cellular imaging, as well as showing strong interest in neurotransmission and synaptic biology.