Jobs in Milano, Italien

HT Flagship Research Programme for Immunogenomics and Cancer. Application closing date: October 2, 2025.

Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian government, with the aim of developing innovative strategies to improve human health. Researchers at HT work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

Flagship Research Programmes at HT are strategic collaborative efforts that leverage the cutting-edge expertise and infrastructure available at HT for translational research focused on different human pathologies.

In the Immunogenomics & Cancer Flagship, we investigate immune diseases and tumors as evolving systems using multi-modal data across spatiotemporal scales. We combine CRISPR-based and drug perturbation assays with spatial transcriptomics in patient-derived models and primary cultures to map the molecular and cellular dynamics of disease progression.

We are seeking a skilled and highly motivated experimental Postdoctoral Researcher to develop and apply a scalable perturbation platform for modelling cancer evolution, under the supervision of Francesco Iorio, Group Leader in Computational Biology. The project focuses on patient-derived gastrointestinal, oesophageal, and brain organoids, and primary immune cell cultures.

The postdoc will play a central role in the:

• generation and interpretation of spatially and temporally resolved perturbation data
• collaboration with computational scientists, platform staff and researchers across multiple HT groups

The work will be highly collaborative and aligned with broader flagship efforts to model disease evolution and drug resistance in complex human systems.

The selected candidate will be actively involved in producing high-impact scientific outputs, including co-first-author publications and protocol-style manuscripts, and will contribute to the dissemination of new experimental methods developed in the context of this project.

Collaborate closely with HT's National Facilities for Genome Editing and Genomics for protocol development and sequencing.

Maintain meticulous records of experimental workflows in accordance with established frameworks and protocols, ensure reproducibility, proper sample tracking, storage, and quality control, and contribute to collaborative data interpretation in line with established protocols.

Lead and co-lead the preparation of scientific publications and dissemination of methods and results.

Present the pipeline, related data and results internally as well as at external national and international meetings and conferences.

Provide technical support and supervision to other laboratory members, including introduction of new laboratory techniques and support in the use of lab equipment.

Required: PhD in a relevant subject (e.g., molecular biology, genetics, biochemistry, or related field of life sciences).

Considerable experience in advanced cellular and molecular biology techniques relevant to genome editing, organoid culture, and drug screening. Practical experience with patient-derived model systems, such as organoids or primary cell cultures, including advanced cell biology techniques. Strong background in molecular biology, including vector design and cloning methods. Familiarity with single-cell and spatial profiling methods, particularly 10x Genomics assays and spatial transcriptomics. Experience with handling large-scale projects. Fluency in English (working language of HT).

Desirable: practical experience with organoid models and protocols; ability to work in a multi-cultural environment with sensitivity and respect for diversity.

Organizational and social skills; ability to lead and gain cooperation of others in a team; strong interpersonal skills; ability to work in a multi-cultural environment.

Please apply online by submitting a single document that includes:

• a motivation letter in English (max 1 page)
• names and contacts of at least 2 referees

HT seeks scientific excellence and recruits the best scientific talents through international, open calls. Our scientists work across disciplines on biomedical topics, leveraging synergies between diverse skillsets and methodological approaches. We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is a core part of our activity, with opportunities for staff including scientific courses, conferences and workshops.

Meal delivery service. Italian language training for foreigners. Parental leave up to 1 year and other support for new parents. Flexible working hours. Relocation support. Tax benefits where applicable.

Contract offered: CCNL Chimico Farmaceutico, Fixed-term - employee level.