Clinical Scientist jobs in United States

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Job Description

Senior Scientist I Analytical Development - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset.

We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared and drives our mission.

We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered.

We encourage applications from individuals of all backgrounds, regardless of background, ethnicity, gender, or expression, status, or any other characteristic protected by law.

• As Senior Scientist I, Analytical Development, help execute analytical strategies across Immunocore's therapeutic project portfolio, driving the development and oversight of robust impurity analytical methods and control strategies.
• Act within cross-functional teams, provide technical consultancy and guide the technical transfer and validation of assays at contract manufacturers.
• Develop and qualify analytical methods for biopharmaceutical process analysis, and process-related impurity testing, including methods such as host cell protein ELISA, 2D Western blotting, host cell DNA and/or endotoxin assays as well as HPLC of residual impurities.
• Contribute to development and control of critical reagents for biopharmaceutical assays.
• Oversee technical transfer and validation of assays at contract manufacturers in line with ICH regulatory guidelines, and develop phase-appropriate specifications.
• Contribute towards relevant sections of CMC regulatory documentation (e.g., IND, IMPD, BLA, MAA) and help responses to agency questions.
• Develop scientists of lower grades within the analytical development team.
• Prepare reports and presentations of high quality suitable for internal and external audiences.
• Independently test and, increasingly, lead lines of investigation. Propose new experiments based on emerging data and other related information. Provide support on technical aspects to others.
• Priorities: establish priorities for own work and team-based projects; make decisions on prioritisation based on overall goals using evidence and experience.
• Technical Knowledge: share knowledge with the wider team and across departments; increasingly provide analysis of new techniques and theories to advance the way the company works and share these with leaders across the Company.
• Laboratory records: ensure that all records and information are up to date, on time and recorded to the correct standard. Laboratory equipment: provide technical guidance to others within the team on how to use equipment effectively; make recommendations regarding acquisition of new equipment. Adhere to safe working practices in laboratories according to Immunocore EHS policies.

Experience & knowledge

• Experience in development of methods for analysis of recombinant proteins or antibodies.
• Worked in a biopharmaceutical laboratory environment.
• Hands-on expertise in SDS-PAGE, Western blotting of proteins and impurity testing experience (one or more of host cell protein ELISA, host cell DNA (qPCR), endotoxin, process residuals).
• Experience with early and late-stage/commercial biopharmaceutical drug programs.
• Presented detailed scientific findings to internal and external audiences.
• Mentored and coached less experienced colleagues in scientific practices and theory.

Desirable

• Experience with HCP coverage assessments and strategy.
• Knowledge of GMP.
• Experience with managing analytical activities at Contract Manufacturers.
• Led a small project team through a change in practice including project management.

Education & qualifications

• Essential: BSc. or MSc. in biochemistry, biotechnology or related discipline.
• Desirable: PhD in related discipline.

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