Germany – PhD in Microfluidic EV Isolation at Heidelberg University

PhDFinder; Heidelberg; On-site; ZAR 300 000 - 400 000; Full time

Job summary

A leading research university in Germany is offering a fully funded PhD position focused on developing microfluidic systems for early cancer detection. This role is geared towards candidates with a strong master's degree in biomedical engineering or related fields, aiming to advance cancer diagnostics through innovative research. Ideal candidates should possess hands-on experience with prototyping techniques and a motivation to work at the interface of engineering and life sciences. Join this prestigious program to make a significant impact in biomedical research.

Qualifications

• Strong background in microfluidics or acoustics is beneficial but not essential.
• Hands-on experience in relevant prototyping techniques is desirable but not mandatory.

Responsibilities

• Designing, prototyping, and testing microfluidic devices for EV enrichment.
• Exploring acoustic trapping principles.
• Integrating ultrasound transducers and materials into prototypes.
• Interfacing microfluidic systems with analytical pipelines.
• Collaborating with biologists and clinicians.
• Contributing to publications and presenting research.

Skills

Motivation to work at the interface of engineering and life sciences

Excellent communication skills in English

Strong team spirit

Curiosity-driven research mindset

Education

Strong master's degree in Biomedical Engineering, Mechanical Engineering, Electrical Engineering, Physics, Chemistry, Molecular Biotechnology, or EV-Biology

Tools

Device prototyping techniques (soft lithography, cleanroom processes, 3D printing)

Job description

University: Heidelberg University
Country: Germany
Deadline: 2026-01-31
Fields: Biomedical Engineering, Mechanical Engineering, Electrical Engineering, Physics, Molecular Biotechnology

Overview

Are you driven by the ambition to revolutionize cancer diagnostics through innovative engineering and biomedical research? If you are eager to contribute to the development of cutting‑edge microfluidic systems for early cancer detection, this fully funded PhD position at Heidelberg University could be your gateway to a transformative academic and professional journey.

About The University

Heidelberg University, established in 1386, is Germany’s oldest university and one of Europe’s leading research institutions. Located in the picturesque city of Heidelberg, the university is renowned for its vibrant academic atmosphere, robust international collaborations, and commitment to interdisciplinary research. With around 31,300 students and 8,400 employees, the university is a cornerstone of the Rhine‑Neckar metropolitan region and consistently ranks among the top universities globally. Students and researchers benefit from state‑of‑the‑art facilities, a supportive academic environment, and access to a dynamic scientific community.

Research Topic and Significance

The primary research focus of this PhD position is the development of innovative acoustofluidic systems for the enrichment of extracellular vesicles (EVs) from microlitre samples. EVs are emerging as powerful biomarkers for early cancer detection, offering non‑invasive, sensitive, and specific insights into disease states. However, isolating and analysing EVs efficiently remains a significant technical challenge. By advancing the physical and engineering foundations of microfluidic EV isolation, this project aims to pave the way for breakthrough applications in cancer diagnostics and therapies. The outcomes of this research have the potential to transform clinical workflows, improve patient outcomes, and contribute to the broader field of biomedical engineering.

Project Details

• Germany – PhD in Machine Learning and Structural Dynamics at Technical University of Berlin
• Luxembourg – PhD in AI and Machine Learning for Biomedical Imaging at University of Luxembourg
• USA – PhD in Human‑Computer Interaction at University of Maine
• USA – PhD in Human‑Computer Interaction at Texas A&M University
• Canada – PhD in Mining Optimization at University of Alberta

Responsibilities

• Designing, prototyping, and testing microfluidic devices for EV enrichment.
• Exploring acoustic trapping principles using frequency/power modulation and material effects.
• Integrating ultrasound transducers, electronics, and materials (such as glass, polymers, and 3D printing) into functional prototypes.
• Interfacing microfluidic systems with analytical pipelines like LC‑MS and ELISA.
• Collaborating with biologists and clinicians to integrate devices into EV workflows.
• Contributing to scientific publications and presenting research at international conferences.

Candidate Profile

• A strong master’s degree in one of the following or related fields: Biomedical Engineering, Mechanical Engineering, Electrical Engineering, Physics, Chemistry, Molecular Biotechnology, or EV‑Biology.
• Background knowledge in microfluidics, acoustics, or related areas (beneficial but not essential).
• Hands‑on experience with device prototyping techniques such as soft lithography, cleanroom processes, or 3D printing (desirable but not mandatory).
• A high level of motivation to work at the interface of engineering and life sciences.
• Excellent communication skills in English.
• A strong team spirit and a curiosity‑driven research mindset.

Application Process

• Curriculum Vitae (CV)
• Cover letter
• Contact information for two references
• A short project idea (maximum 1 page) outlining how you could contribute to the research project
• A portfolio of technical skills relevant to the project (maximum 1/2 page)

Conclusion

This is a unique opportunity to join a world‑class research university in Germany and contribute to the advancement of early cancer detection technologies. If you are motivated to work at the interface of engineering and life sciences and aspire to make a tangible impact in biomedical research, consider applying for this prestigious PhD position at Heidelberg University.
For further information, visit the official position page: https://www.imseam.uni-heidelberg.de/de/node/1384