Principal Scientist, Oligonucleotide Chemistry Research

Scorpion Therapeutics; Barrio San Diego Pueblo Nuevo; Presencial; MXN 1,043,000 - 1,391,000; Jornada completa

Descripción de la vacante

A biotechnology firm located in Mexico is looking for a highly motivated chemist/biochemist to design and synthesize siRNA-based therapeutics. The ideal candidate will have extensive experience in the pharmaceutical industry, leading projects in drug discovery, focusing on neurology and related therapeutic areas. Responsibilities include managing synthesis chemistry and collaborating with various teams to drive project success. A PhD is preferred along with strong problem-solving skills and scientific excellence.

Formación

• 7+ years of experience in the pharmaceutical industry and prior managerial experience.
• Demonstrated scientific excellence in oligonucleotide/siRNA chemistry.
• Strong understanding of the drug discovery process for siRNA.

Responsabilidades

• Design, synthesize and characterize novel siRNA oligonucleotides.
• Setup internal siRNA synthesis chemistry capability.
• Participate in and lead cross-functional discovery projects.

Conocimientos

Scientific communication and collaboration

Analytical thinking and problem solving

Project leadership and cross-functional teamwork

Bioconjugation and targeted delivery technologies

Strategic planning and result-oriented execution

Educación

PhD in chemistry or related field

MS/MA degree

BS/BA degree

Descripción del empleo

Role Summary

The ideal candidate is a highly motivated and accomplished chemist/biochemist with a proven track record of success in designing and synthesizing oligonucleotide-based molecules and optimizing them towards the clinical development candidate stage. The candidate will work in a fast-paced environment and play a key role in the discovery of next-generation siRNA-based therapeutics for our three therapeutic areas of interest: neurology, neuroendocrinology, and neuroimmunology.

Responsibilities

• Design, synthesize and characterize novel siRNA oligonucleotides, siRNA libraries, and collaborate with the Bioconjugation team where applicable to generate novel oligo-based Bioconjugates
• With a strong lab presence, setup internal siRNA synthesis chemistry capability in collaboration with the Director, Oligonucleotide Chemistry
• Participate in and/or lead cross-functional discovery projects and project teams
• Drive the development and incorporation of novel technologies, methods, oligonucleotide modifications into the Oligonucleotide Chemistry team
• Collaborate closely with the broader research team by communicating results, sharing insights, making plans, and setting goals in an open and collaborative way to enable project success
• Anticipates potential issues and provides contingencies and resolutions to continuously improve that process
• Aid in the evaluation of external partnering opportunities
• Performs other duties as assigned

Qualifications

• PhD (preferred) in chemistry or related field and 7+ years of experience in the pharmaceutical industry and prior managerial / functional management experience
• MS/MA degree and 10+ years of similar experience as noted above, OR
• BS/BA degree and 12+ years of similar experience
• Demonstrated scientific excellence in oligonucleotide/siRNA chemistry or related research, as evidenced by significant patents and/or publications in the field
• Demonstrated delivery of clinical candidate siRNA-based molecules
• Expert understanding of the drug discovery process for siRNA
• Thorough understanding of developability and associated assays
• Experience and knowledge in protein bioconjugation and/or targeted delivery technologies is strongly preferred
• Overall strong work ethic and willingness to engage in projects across therapeutic areas
• Applies in-depth knowledge of own function, business / commercial / scientific expertise to solve critical issues successfully and innovatively
• Evaluates key business / scientific challenges and completes complex, ambiguous initiatives having cross-functional impact
• Sees broader picture, impact on multiple programs, teams and/or departments
• Ability to effectively interact with multiple functions across the organization, and effectively communicate results and strategies to staff and company executives
• Strong attention to detail; excellent written, oral and interpersonal communication skills
• Excellent problem solving and analytical thinking skills

Skills

• Scientific communication and collaboration
• Analytical thinking and problem solving
• Project leadership and cross-functional teamwork
• Bioconjugation and targeted delivery technologies (preferred)
• Strategic planning and result-oriented execution