Principal scientist, Oncology (3D In Vitro Modelling - Micofluidics)

GSK; England; Hybrid; GBP 60,000 - 80,000; Full time

Job summary

A leading pharmaceutical company in the UK is seeking a highly motivated Principal Scientist to join their Oncology Translational Research team. The ideal candidate will have a strong background in microfluidics and oncology cellular biology, contributing to the development of innovative organoid-on-a-chip platforms. This position allows for a hybrid working model, combining lab-based work with some flexibility. Competitive salary and benefits are offered.

Benefits

Competitive salary

Annual bonus based on performance

Healthcare and wellbeing programmes

Pension plan membership

Shares and savings programme

Qualifications

• MSc in relevant fields is required.
• Experience with 3D organ-on-a-chip systems is essential.
• Ability to communicate across diverse teams and stakeholders.

Responsibilities

• Establish organoid-on-a-chip platforms with multiple cell types.
• Develop a microfluidic system for immune cell modeling.
• Collect and report data to the laboratory head.

Skills

Experience in microfluidics

Fluorescence microscopy

Label-free microscopy

Oncology cellular biology

3D organ-on-a-chip systems

Education

MSc in Cell Biology/Oncology/Biotechnology/Bioengineering/Chemical Biology

Tools

Microfluidic devices

Imaging systems

Job description

Overview

427676 Principal scientist, Oncology (3D In Vitro Modelling - Microfluidics)

We are looking for a highly motivated scientist with experience in microfluidics, fluorescence and label-free microscopy, applied to complex in vitro systems (organoid, immune cells, fibroblasts and tissues) and extensive oncology cellular biology to join the Oncology Translational Research team within GSK Oncology.

The Oncology Translational Research team will partner with other Oncology Therapy Area team members to increase clinical translatability and to contribute to preclinical development programs within GSK Oncology TA.

The successful candidate will work in a small team involved in the establishment of a new organoid-on-a-chip platform combined with a microfluidic system and single cell detection. This research platform will be used to develop and implement cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, generating data that will inform machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

Please note that this position will need to be predominantly lab-based with some ad hoc flexibility to work from home.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

• Establish organoid-on-a-chip platforms that incorporate multiple cell types (immune cells/ fibroblasts/tumour cells/endothelial cells)
• Develop a microfluidic system for modelling immune cell action and drug penetration into 3D organoid models
• Develop protocols for whole-organoid imaging as well as single-cell analysis
• Data collection and reporting to the laboratory head
• Execute and deliver the project

Why you?

Basic Qualifications & Skills:

• MSc in Cell Biology/Oncology/Biotechnology/Bioengineering/Chemical Biology
• Experience in 3D organ-on-a-chip systems and single cell analysis on patient-derived organoids
• Experience in microfluidic and chip devices, including device fabrication
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result-oriented attitude

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• PhD in Cell Biology/Oncology or Bioengineering/Chemical Biology
• Laboratory automation experience
• Experience with cancer immunology
• Experience in wide-field imaging and/or confocal microscopy
• Any additional experience in advanced light microscopy and quantitative imaging techniques

Closing Date for Applications - 29th of September, 2025 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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