Postdoctoral position in DNA repair, genome instability and mutagenesis

CNRS; France; Sur place; EUR 35 000 - 45 000; Plein temps

Résumé du poste

A prestigious research organization in France is offering a postdoctoral position to explore genetic and molecular mechanisms of DNA damage tolerance pathways in E. coli. The ideal candidate will hold a PhD in molecular biology and have familiarity with DNA damage research. This position is open for 2-3 years with potential for independent funding applications. The role involves collaboration with research groups at Harvard Medical School and Institut Gustave Roussy.

Qualifications

• PhD in molecular biology or a related field required.
• Familiarity with the field of DNA damage is essential.
• Experience in microbiology is desirable but not mandatory.

Responsabilités

• Explore genetic and molecular mechanisms of DNA damage tolerance pathways in E. coli.
• Identify new factors involved in lesion tolerance pathways using a dead-Cas9 system.
• Characterize the role of these factors through computational analyses and molecular approaches.

Connaissances

Familiarity with DNA damage

Microbiology experience

Formation

PhD in molecular biology or related field

Description du poste

Organisation/Company CNRS Department CRCM Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country France Application Deadline 28 Feb 2026 - 12:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Apr 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Cancer Research Center of Marseille (CRCM) is located within the Paoli-Calmettes Institute, a comprehensive cancer institute. Its goal is to improve the knowledge of the biology and medicine of cancer through a continuum between basic, translational and clinical research.

The team "DNA damage and genome instability" led by Dr. Vincent Pagès is part of the “Genome Integrity department” at CRCM. The team aims to understand the biological consequences of the replication of damaged genomes which is the major source of point mutations, and the initiating cause of cancer.

The team has developed a method to introduce a single lesion in the genome of a living cell (bacteria and yeast), allowing them to monitor the fate of this lesion in vivo.

The proposed postdoctoral research project will explore the genetic and molecular mechanisms of DNA damage tolerance pathways in E. coli. We will identify new factors involved in lesion tolerance pathways by pulling down the damaged region using a dead-Cas9 system. We will then characterize the role of these factors and identify their partners by using a combination of computational analyses, single molecule imaging and molecular approaches such as Electron Microscopy. The project will be realized in collaboration with research groups at Harvard Medical School (Boston – USA) and Institut Gustave Roussy (Paris – France).

Profile:

The candidate should have a PhD in molecular biology or related field and must be familiar with the field of DNA damage. Experience in microbiology is recommended but not mandatory.

Position:

The position is currently open and funded for 2-3 years by an ANR grant. With the full support of the PI, the candidate is also encouraged to apply for his/her own funding.