Postdoctoral Fellow in ubiquitin biology research

European Molecular Biology Laboratory; Grenoble; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A leading research laboratory is seeking a passionate postdoctoral researcher to explore understudied ubiquitin ligases. Responsibilities include conducting innovative research and collaborating within a dynamic team. Ideal candidates hold a PhD and have a strong background in quantitative proteomics and molecular biology. The position offers a monthly stipend, professional development support, and a range of employee benefits including private medical insurance and generous leave.

Prestations

Financial incentives

Flexible working arrangements

Private medical insurance

30 days annual leave

Free shuttle bus to work

Subsidised gym and cafeteria

Paid maternity & parental leave

Qualifications

• PhD in Biochemistry / Cell biology or related field required.
• At least one first author research article/preprint essential.
• Experience in quantitative proteomics and related applications.

Responsabilités

• Conduct research related to human ubiquitin ligases.
• Collaborate with team members on translational research.

Connaissances

Quantitative proteomics understanding

Molecular biology techniques

Immunofluorescence microscopy

CRISPR / Cas9 engineering

Lentiviral transductions

Formation

PhD in Biochemistry / Cell biology

Outils

Mass spectrometry

Alphafold

Description du poste

Bhogaraju group at EMBL Grenoble has several postdoc positions open to conduct fundamental and translational research into a class of understudied human ubiquitin ligases. Our group explores Melanoma-associated antigen (MAGE)-RING ubiquitin ligases (MRLs) some of which are highly oncogenic. We are looking for passionate and ambitious colleagues who are willing to make significant fundamental discoveries related to the medically relevant MRLs and their ubiquitination substrates.

Our recent work includes the discovery of a conserved ligase-binding cleft in MAGE proteins showcasing (Griffith-Jones et al. 2024). We also developed a proteomics-based ubiquitin ligase-substrate mapping method known as Ub-POD which is being widely used in the field (Mukhopadhyay et al. 2024). Bhogaraju group uses Proteomics cell biology and structural biology methods to study human ubiquitin ligases especially MRLs. See further information at lab webpage profile

Required qualifications :

• A PhD in Biochemistry / Cell biology or related field
• At least one first author research article / preprint
• Strong understanding of quantitative proteomics and its applications
• Proficiency in common molecular biology and cell biology techniques
• Immunofluorescence microscopy
• CRISPR / Cas9- based cell engineering
• Experience in Lentiviral transductions

Preferred qualifications :

• Expertise in mass spectrometry data analysis
• Basic understanding of protein structural biology and Protein structure analysis
• Alphafold
• Cancer biology background and translational research

Preferred personal attributes :

• Strong team player with willingness to collaborate
• Proactive in decision-making
• Critical thinker with strong problem-solving abilities

Contract length : 2 years (with the possibility of extension)

Salary : Monthly stipend (first year) : 3.64624 (after tax excl. pension & insurances) benefits

Professional development support

The EMBL Fellows Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBLs sites.

Working with a dedicated Careers Advisor this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia exploring opportunities in industry or exploring an independent venture the EMBL Fellows Career Service with provide you with a portfolio of activities and resources to help you.

To find out more please visit - EMBL-fellows-career-service

Why join us

Join a culture of innovation

We are located on the Wellcome Genome Campus alongside other prominent research and biotech organisations and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued supported and empowered to reach their professional potential.

Enjoy lots of employee benefits :

Financial incentives : Monthly family and child allowances generous stipend reviewed yearly pension scheme death benefit and unemployment insurances

Flexible working arrangements including hybrid working patterns

Private medical insurance for you and your immediate family

Generous time off : 30 days annual leave per year in addition to public holidays

Campus life : Free shuttle bus to and from work (Heidelberg) on-site library subsidised on-site gym and cafeteria casual dress code extensive sports and social club activities (on campus and remotely)

Family benefits : Kindergarten (Heidelberg) 10 days of child sick leave paid maternity & parental leave holiday clubs on campus and monthly family and child allowances

What else you need to know

International applicants : We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.

Diversity and inclusion : At EMBL we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women LGBTQ & individuals from all nationalities.

Job location : All our fellowships are based on-site (for at least part of each week). If you are living overseas you will receive a generous relocation package to support you.

EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here

How to apply : To apply please submit a cover letter and a CV through our online system. Applications will close at 23 : 59 CET on the date shown below. We aim to provide a response within two weeks after the closing date.

Closing Date

07 / 12 / 2025

Key Skills

Virology,Bioinformatics,Genetics,R,Biochemistry,Cell Biology,Research Experience,Spectroscopy,Cell Culture,Molecular Biology,Microscopy,Research Laboratory Experience

Employment Type : Full-Time

Experience : years

Vacancy : 1