Marie Sklodowska Curie Action - Postdoctoral individual Fellowship at IPBS-Toulouse, France (En[...]

euraxess.ec.europa.eu - Jobboard; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading research institute in France seeks a postdoctoral researcher to investigate T cell dynamics in mycobacterium tuberculosis infection. Candidates should have a PhD in immunology or related fields and expertise in intravital microscopy and tissue analysis. This role offers involvement in cutting-edge research and career development support. The starting date ranges from September 2026 to September 2027, depending on funding. Detailed applications, including a CV and cover letter, are due by 15 January 2025.

Prestations

Career development support

Vibrant international research community

Qualifications

• Candidates must hold a PhD or will have it before the application deadline.
• Experience in animal experimentation and tissue analysis is required.
• Good laboratory practices and animal experimentation certification are necessary.

Responsabilités

• Conduct research on T cell behavior in pulmonary TB.
• Utilize advanced imaging techniques under BSL3 conditions.
• Collaborate within a vibrant international research community.

Connaissances

T cell immunity and dynamics

Migration of T cells in tissues

Formation

PhD in immunology, pathophysiology, or in vivo imaging

Outils

Intravital and fluorescence microscopy

Image analysis software (Imaris, ImageJ)

Immunology techniques and flow cytometry

Data analysis

Description du poste

Organisation / Company Centre National de la Recherche Scientifique, Université de Toulouse Department Biology Laboratory Institute of Pharmacology and Structural Biology (Toulouse, France) Is the Hosting related to staff position within a Research Infrastructure? No

The IPBS (Institute of Pharmacology and Structural Biology) is seeking motivated postdoctoral researchers to apply for Marie Skłodowska‑Curie fellowships and join our laboratory to carry out their research project.

• Research topic

Real‑time visualization of pulmonary T cell dynamics during mycobacterium tuberculosis infection

Tuberculosis (TB) remains the leading cause of infectious mortality worldwide, largely due to an incomplete understanding of protective T cell immunity. While T lymphocytes are crucial for controlling Mycobacterium tuberculosis (Mtb), their limited efficacy may originate from their exclusion from granuloma cores, where infected macrophages reside. The mechanisms governing this spatial segregation remain poorly defined.

This project aims to elucidate, in real time and in vivo, T cell dynamics within pulmonary granulomas using lung intravital microscopy (LIVM) established under BSL3 conditions, an exclusive setup in Europe. This approach allows direct visualization of T cell migration, activation, and interactions in the Mtb‑infected lung. We will compare T cell behaviors in murine models with distinct susceptibility profiles, analyze how the extracellular matrix regulates T cell access to infected macrophages, and determine whether high endothelial venules (HEVs) act as preferential T cell entry points. The project’s originality lies in the first application of pulmonary IVM to TB under BSL3 containment. Through integration of advanced imaging, genetic models, and local and international collaborations (Neyrolles laboratory - IPBS Toulouse, Joel Ernst - UCSF), this project will uncover structural and molecular barriers limiting T cell efficacy and provide new strategies to optimize T cell responses against TB.

Experience/Skills required:

• Candidates must hold a PhD or having it before the application deadline

We are seeking a highly motivated postdoctoral researcher with a PhD in immunology, pathophysiology, or in vivo imaging, and expertise or strong interest in:

• T cell immunity and dynamics
• Migration of T cells in tissues

The ideal candidate will have experience in:

• Animal experimentation and tissue analysis
• Intravital and fluorescence microscopy
• Image analysis (Imaris, ImageJ, or equivalent)
• Immunology techniques and flow cytometry
• Data analysis and scientific communication
• Good laboratory practices and animal experimentation certification

Join our team to investigate T cell behavior in pulmonary TB using cutting‑edge imaging approaches in a dynamic, collaborative research environment.

✅ Work at the cutting edge of molecular biology, structural biology, imaging, and omics technologies in Toulouse, France
✅ Join a vibrant international research community, with connections across Toulouse and throughout Europe

✅ Benefit from career development support, including mentoring for fellowship writing, networking, and future job applications

• Application Process
• Send a detailed CV, a cover letter outlining your research interests and motivation for joining the group, and the contact information of at least 2 professional references (potential supporters and mentors) to:
• Internal deadline: 15 January 2025

Don’t hesitate to apply now as applications will be reviewed on a rolling basis.

• Expected Starting date: From September 2026 to September 2027 depending on the funding