Postdoctoral Position in Multiscale Simulations of RNA-Driven Condensates (M/F)

CNRS; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

A leading research institution in France seeks a motivated postdoctoral researcher in molecular modeling. This role involves developing multiscale simulation strategies to explore RNA-driven phase separation in cells. The ideal candidate has experience in molecular simulations, programming skills, and a solid grounding in statistical mechanics. Join a vibrant scientific community at the forefront of biophysics and structural biology, contributing to groundbreaking research with real-world applications.

Qualifications

• Proven experience in molecular simulations, atomistic and/or coarse-grained.
• Good programming/scripting skills in Python, C/C++ or similar.
• Solid understanding of statistical mechanics and thermodynamics.

Responsabilités

• Develop and apply advanced multiscale simulation strategies.
• Investigate the molecular mechanisms of RNA-driven condensate formation.
• Explore design principles for programmable intracellular compartments.

Connaissances

Molecular simulations

Programming/Scripting skills (Python, C/C++)

Understanding of statistical mechanics

Curiosity and collaborative mindset

Formation

Ph.D. or equivalent in a relevant field

Description du poste

Biological sciences » Biological engineering

Organisation/Company CNRS Department Centre de biologie structurale Research Field Chemistry » Biochemistry Physics » Biophysics Biological sciences » Biological engineering Researcher Profile First Stage Researcher (R1) Application Deadline 23 Jan 2026 - 00:00 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

This position offers a unique opportunity to explore how RNA molecules shape cellular organization through phase separation, combining physics-based modeling with close collaboration across disciplines.

The postdoctoral researcher will develop and apply advanced multiscale simulation strategies, at both atomistic and coarse-grained resolutions, to investigate the molecular mechanisms of RNA-driven condensate formation and organization in cells. The goal is to elucidate the sequence–structure–function relationships that govern RNA-mediated phase separation and to explore how these principles can be harnessed to design programmable intracellular compartments for synthetic biology applications.

This research is conducted within the framework of the ANR SYNORG project (Transcriptionally Engineered Addressable RNA Solvent droplets as generalized synthetic organelles). The project will involve close interaction with experimental and computational partners, including Ariel Lindner (Université Paris Cité) and Sarah Berkemer (LIX, École Polytechnique).

The CBS (INSERM U1054, CNRS 5048, Université de Montpellier) is a leading centre for biophysics and structural biology, hosting state-of-the-art facilities for cryo-EM, advanced fluorescence and super-resolution microscopy, molecular and cell biology, and high-performance computing. Montpellier offers a vibrant international scientific community, an exceptional research environment, and a high quality of life in southern France.

Research Field Biological sciences » Biological engineering Years of Research Experience None

Additional Information

Eligibility criteria

We are looking for a motivated and focused researcher with a strong background in molecular modeling and its theoretical foundations. The ideal candidate should have a genuine interest in developing and applying simulation methods to address complex biological questions.

Essential qualifications are:

• Proven experience in molecular simulations (atomistic and/or coarse-grained),
• Good programming/scripting skills (Python, C/C++ or similar),
• Solid understanding of the physical principles underlying molecular simulations (e.g., statistical mechanics, thermodynamics), and
• Motivation, curiosity, and a collaborative mindset.

Experience with modeling of RNA or biomolecular condensates and/or method development in molecular simulations will be considered an asset. The postdoctoral researcher will be encouraged to develop independent ideas and collaborations within and beyond the SYNORG consortium.