Post-Doc position (organic chemistry and photophysics) – ICMUB – Dijon

France Life Imaging; Dijon; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

An academic research institution in Dijon is offering a post-doc position in organic chemistry to develop innovative fluorescent markers for medical imaging. The role requires a Ph.D. in organic chemistry, with strong skills in synthesis and analytical techniques. Candidates should possess rigorous experimental skills and good communication abilities. This is a 24-month position aimed at contributing to a multidisciplinary project in medical diagnosis.

Qualifications

• Good theoretical and practical knowledge in photophysics.
• Proactive attitude towards problem solving and scientific watch.
• Rigorous in experimental work and handling high value compounds.

Responsabilités

• Design and synthesize new classes of NIR-emissive organic-based fluorophores.
• Optimize structural properties of fluorescent contrast agents.
• Explore use of fluorescent markers in biolabeling and probe construction.

Connaissances

Organic synthesis

Analytical chemistry

Chromatographic techniques

Spectroscopic techniques

Problem solving

Communication skills

Formation

Ph.D. in Organic Chemistry

Outils

HPLC

HPLC-MS

Description du poste

Type de structure

Our research group at ICMUB lab. (UMR 6302, Univ. Bourgogne Franche-Comté, CNRS, Dijon, http://www.icmub.com/), recognized as one of the leading French academic players in the field of "Chemistry for Molecular Imaging", is offering a 24-month post‑doc position (preferred starting date: October 2022).

Contexte et mission

The candidate will be recruited by the Université de Bourgogne and his/her research will be conducted within the context of an European project named "CoDaFlight" and led by a cross-disciplinary consortium (electronic and biomedical-engineers, physicists, chemists, medical scientists, and clinicians). The primary goal of this project is to develop a cutting‑edge approach for multi-domain fluorescence imaging based on lifetime measurements, to address challenges in medical diagnosis.

Specifically, the aim of the post‑doc work is to design, synthesize and perform structural optimization of emerging/promising classes of NIR‑emissive organic‑based fluorophores, especially derived from those developed in our group (Bodipys or aza‑Bodipys, diketopyrrolopyrroles (DPPs)), that will be used as lifetime‑tunable fluorescent contrast agents. Ability of these novel fluorescent markers to act as effective biolabeling reagents and/or valuable scaffolds for the construction of bioanalyte‑responsive fluorogenic probes, will also be explored.

Candidate profile

Ph.D. in organic chemistry with a good theoretical and practical knowledge in photophysics, truly interested in organic synthesis and analytical chemistry, in particular the chromatographic techniques (semi‑preparative HPLC, HPLC‑MS, ...) and advanced spectroscopic techniques (steady‑state and time‑resolved fluorescence, ...). Rigor and care in the experimental work (small scale syntheses, handling of high added‑value compounds, ...), proactive attitude towards problem solving and scientific watch, acute sense of ethics and organization, and good drafting/communication skills are required. A first meaningful research experience in chemistry and photophysics of fluorophores and/or "smart" fluorescent probes, may be a valuable asset but not mandatory.

Application documents

Detailed CV (+ 2-3 references), a brief summary of research works and a detailed covering letter.

Website

Please visit website of the analytical platform PACSMUB: http://wpcm.fr/index.php?page=presentation-generale

Contact

Dr. Christine GOZE, [e-mail]
Prof. Franck DENAT, [e-mail]
Prof. Anthony ROMIEU, [e-mail]