2016/08/26 Post-doctoral position in pre-clinical ultrasound and optical imaging, Paris

France Life Imaging; Paris; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading imaging facility in Paris is offering a 2-year post-doctoral position in pre-clinical ultrasound and optical imaging. The role involves investigating a new strategy for rheumatoid arthritis treatment using advanced imaging techniques. Candidates with experience in ultrasound image formation are encouraged to apply, along with a motivation letter and CV by the specified deadline.

Qualifications

• Strong experience in ultrasound image formation required.
• Experience in small animal experimentation appreciated.

Responsabilités

• Implement imaging tools for therapy assessment in preclinical models of rheumatoid arthritis.

Connaissances

Experience in ultrasound image formation

Ultra-fast sequence computing

Description du poste

Job Title: Post-doctoral position in pre-clinical ultrasound and optical imaging, Paris

Company Description: The small animal imaging facility of Institut Cochin performs studies in ultrasound and bioluminescence imaging for both academic teams and private companies. It is specialized in in vivo evaluation and characterization of pathologies and runs 2 high resolution scanners (VEVO 2100, VEV0770, Visualsonics) and one ultrafast ultrasound scanner (Aixplorer, Supersonic Imagine). Our team has also strong experience in the development and evaluation of mice models of rheumatic diseases and their imaging using various modalities (ultrasound, bioluminescence, MRI, CT, ..).

Job Description: Our team is involved in the H2020 European Project Folsmart dedicated to the treatment of rheumatoid arthritis using a new strategy targeting folate receptors with a liposome-based nanovector. We are in charge of the pre-clinical evaluation of this nanovector and the investigation of its mechanism of action in mice. We will use in vivo imaging techniques to address these questions, including high resolution ultrasound, opto-acoustics (also called photoacoustics), in vivo bi-photon imaging and ultra-fast ultrasound imaging.

We offer a 2-year post-doctoral position to implement these tools in order to characterize and provide early assessment of the therapy in preclinical models of rheumatoid arthritis. Date of Employment should be between 17th October and the end of December 2016.

References:

• Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice. Nogueira E, Lager F, Le Roux D, Nogueira P, Freitas J, Charvet C, Renault G, Loureiro A, Almeida CR, Ohradanova-Repic A, Machacek C, Bernardes GJ, Moreira A, Stockinger H, Burnet M, Carmo AM, Gomes AC, Preto A, Bismuth G, Cavaco-Paulo A. J Biomed Nanotechnol. 2015 Dec;11(12):2243-52.
• Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice. Clavel G, Marchiol-Fournigault C, Renault G, Boissier MC, Fradelizi D, Bessis N. Ann Rheum Dis. 2008 Dec;67(12):1765-72.
• Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array. Gateau, J., Gesnik, M., Chassot, J.-M., & Bossy, E. (2015). Journal of Biomedical Optics, 20(5), 056004.

Requirements: Applicant must have a strong experience in ultrasound image formation and ideally in ultra-fast sequence computing. Previous experience on small animal experimentation is not mandatory but would be appreciated.

Contact: Applicants should submit a letter detailing her/his motivation and skills to take over the project with a curriculum vitae including a full list of publications and references by 30th September 2016 to gilles.renault[at]inserm.fr