Principal Scientist - Metabolic Diseases/In Vivo Pharmacology

Sygnature Discovery; Nottingham; On-site; GBP 60,000 - 80,000; Full time

Job summary

A leading drug discovery organization in Nottingham is seeking a Senior Principal Scientist to provide scientific leadership in metabolic disorders. This fully onsite role involves overseeing in vivo pharmacology and drug discovery projects, championing scientific advancements, and mentoring team members. Candidates should have a PhD or equivalent industry experience, with a deep understanding of metabolic diseases and a proven track record in drug discovery. This position offers an opportunity to contribute significantly within a fast-paced research environment.

Benefits

25 days annual leave plus bank holidays

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Enhanced Family Friendly Policies

Sygnature Group Pension Scheme

1 paid volunteer day per year

Qualifications

• PhD in a relevant discipline with drug discovery experience or a BSc/MSc in a relevant discipline with significant industry experience.
• Strong technical expertise in metabolic diseases and in vivo pharmacological research methods.
• Understanding of UK/European legislation governing in vivo research.

Responsibilities

• Provide scientific leadership in the metabolic disease portfolio.
• Act as a Project Lead for research projects.
• Collaborate internally and with clients on drug discovery projects.

Skills

Drug discovery experience

In vivo pharmacology expertise

Problem-solving skills

Organisational skills

Education

PhD in a relevant discipline

BSc/MSc in a relevant discipline

Job description

We're looking for an experienced Senior Principal Scientist with expertise in metabolic disorders to join our In Vivo Pharmacology team in Nottingham. This is a fully onsite role based in the heart of Nottingham's city centre. You will use your strong experience and expertise in drug discovery and In Vivo Pharmacology to play a significant role in operational and leadership responsibilities across the department, as well as championing, leading, and driving progression of the science in the department.

Responsibilities

• Provide scientific leadership in the metabolic disease portfolio by guiding and overseeing in vivo pharmacology and drug-discovery programs, guiding and mentoring team members, and driving innovative experimental and technological solutions to advance project success. Line manager duties may be part of the role.
• Act as a Project Lead for research projects, responsible for coordinating the delivery of high‑quality science.
• Collaborate successfully internally and with clients to design and drive complex drug discovery projects.
• Use excellent problem‑solving skills to make informed decisions and deliver innovative solutions to complex scientific and technical challenges.

Qualifications

• PhD in a relevant discipline, with drug discovery experience in industry and/or other relevant Post‑doctoral activities. Alternatively, BSc/MSc in a relevant discipline with significant drug discovery experience in industry is also suitable.
• This role requires strong technical expertise and a deep understanding of metabolic diseases (obesity, diabetes, cardiometabolic diseases) with proven experience in applying in vivo pharmacological research methods to study these conditions. Expert knowledge in the end‑to‑end drug discovery pathway and of current therapeutic landscape is advantageous.
• Good understanding of current UK/European legislation governing in vivo research and direct experience in the experimental design and oversight of in vivo studies is advantageous.
• Significant drug discovery experience gained from an industrial environment.
• Experience working effectively in a fast‑paced team environment.
• Excellent organisational and data‑management skills and a proven ability to work across several projects concomitantly.

Sygnature Discovery is a world‑leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.

Since 2004, Sygnature Discovery has delivered over 56 novel pre‑clinical and 35 clinical compounds, with its scientists named on over 225 patents. Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, and more. To find out more, please visit www.Sygnaturediscovery.Com.

Benefits

• 25 days annual leave (plus bank holidays)
• Private Medical Insurance
• Life Insurance
• Employee Assistance Programme
• Enhanced Family Friendly Policies
• Sygnature Group Pension Scheme
• 1 paid volunteer day per year