Senior USP / DSP Engineer

S3 Science Recruitment; Paris; Sur place; EUR 50 000 - 80 000; Plein temps

Résumé du poste

A biotech recruitment agency in Île-de-France is seeking an experienced candidate to lead fed-batch cell-culture process development and manage a team of engineers. The role requires a PhD in biochemical engineering and hands-on expertise with CHO cell systems, along with strong communication skills. Responsibilities include optimizing media formulations and overseeing experimental campaigns. This position offers a dynamic and collaborative work environment.

Qualifications

• At least 3 years of relevant experience in biotech, pharma, or CDMO environment.
• Experience with bioreactor operations from laboratory scale through pilot scale.

Responsabilités

• Lead the development of fed-batch cell-culture processes.
• Supervise and mentor a team of engineers focusing on cell-culture media formulation.
• Design and optimize chemically defined and custom media.
• Specify and help implement bioproduction equipment.
• Plan and oversee experimental campaigns in bioreactors.

Connaissances

Hands-on expertise with CHO cell systems

Strong understanding of cellular metabolism

Excellent written and verbal communication skills in English

Formation

PhD in biochemical engineering, bioprocess engineering, or bioproduction

Description du poste

Main Responsibilities

• Lead the development of fed-batch cell-culture processes at the R&D scale and ensure smooth transfer, optimization, and scale-up toward pilot operations.
• Supervise, mentor, and support a team of engineers focusing on cell-culture media formulation, promoting scientific excellence and experimental rigor.
• Design and optimize chemically defined (CD), animal-component‑free (ACF), and custom media, making use of metabolic modeling, data-driven analysis, and multiparametric approaches.
• Specify, evaluate, and help implement bioproduction equipment, including media‑prep systems, bioreactor platforms, PAT sensors, and automation solutions.
• Plan, execute, and oversee experimental campaigns across shake‑flask systems and benchtop bioreactors, with detailed monitoring of key CPPs and CQAs.
• Develop and refine analytical methods and PAT strategies (e.g., online viability, Raman spectroscopy, metabolomics) to enhance real‑time monitoring and advanced process control.
• Implement analytical workflows for characterizing the quality attributes of biotherapeutic molecules such as biosimilars and recombinant proteins.

Required Profile

• PhD in biochemical engineering, bioprocess engineering, or bioproduction, with at least 3 years of relevant experience, ideally within the biotech, pharma, or CDMO environment.
• Hands‑on expertise with CHO cell systems and development of recombinant protein processes (mandatory).
• Demonstrated experience with bioreactor operations from laboratory scale through pilot scale, including process optimization.
• Strong understanding of cellular metabolism and its application to process development.
• Experience with downstream processing (DSP) and quality‑attribute profiling is an asset.
• Ability to tackle complex scientific challenges through literature review, technology scouting, and critical analysis.
• Collaborative mindset, strong scientific curiosity, and motivation to contribute to the growth of an expanding organization.
• Excellent written and verbal communication skills in English.