Research Assistant /Associate(Medicine) (CHB)

NATIONAL UNIVERSITY OF SINGAPORE; Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A leading academic institution in Singapore seeks candidates for research related to chronic hepatitis B. The role involves performing cell cultures, conducting molecular assays, and collaborating with clinical teams. Applicants must have a Bachelor’s degree in Life Sciences and relevant laboratory experience. This position offers exposure to cutting-edge research platforms and substantial opportunities for publication, making it ideal for those aiming for a PhD or a career in biomedical research.

Benefits

Training opportunities

Exposure to high-impact research

Networking with national HBV consortia

Qualifications

• Bachelor’s degree in a relevant field, recent graduates welcome.
• Essential experience in cell culture and molecular biology.
• Experience with hepatocyte or viral systems advantageous.
• Strong work ethic and curiosity to learn quickly.
• Excellent organizational and communication skills.

Responsibilities

• Perform cell culture and molecular assays.
• Conduct HBV replication and gene expression analyses.
• Assist with RNA therapeutics and delivery studies.
• Maintain experiment records and safety documentation.
• Support data analysis and visualization.
• Collaborate with clinical teams on the project.

Skills

Cell culture

Molecular biology

Analytical skills

Teamwork

Communication skills

Education

Bachelor’s degree in Life Sciences, Biomedical Sciences, or Molecular Biology

Tools

Excel

GraphPad

Python

R

Job description

Interested applicants are invited to apply directly at the NUS Career Portal

Your application will be processed only if you apply via NUS Career Portal

We regret that only shortlisted candidates will be notified.

Job Description

Chronic Hepatitis B (CHB) remains a major global health challenge, and functional cure, defined by HBsAg loss and immune restoration, is rarely achieved.

Our multidisciplinary program integrates clinical cohorts with mechanistic laboratory studies to uncover how hepatocytes transition from a pro-viral tolerant state to an immune-reactive flare state that precedes viral clearance.

This research aims to identify molecular triggers and therapeutic targets that drive immune-mediated HBV flares, combining hepatocyte biology, RNA therapeutics, and spatial transcriptomics.

Key Responsibilities

• Perform cell culture and molecular assays (HepAD38, HepG2, Huh7, primary hepatocytes, and co-culture systems).
• Conduct HBV replication and gene expression analyses (RNA/DNA extraction, qPCR, ELISA, Western blotting).
• Assist with RNA therapeutics and GalNAc-ASO delivery studies in hepatocyte models.
• Maintain meticulous experimental records, reagent inventories, and safety documentation.
• Support data analysis and visualization (Excel, GraphPad, or Python/R if skilled).
• Liaise with clinical teams and collaborators on translational aspects of the project.

Qualifications

• Bachelor’s degree in Life Sciences, Biomedical Sciences, or Molecular Biology (recent graduates are welcome).
• Prior experience in cell culture and molecular biology is essential.
• Experience with hepatocyte or viral systems (HBV, HCV, etc.) is an advantage.
• Strong work ethic, curiosity, and ability to learn new techniques quickly.
• Excellent organizational, communication, and teamwork skills.

Training & Opportunities

• Exposure to cutting-edge platforms: RNA therapeutics, AAV-HBV1.2 mouse models, and spatial transcriptomics (CosMx).
• Opportunity to contribute to high-impact publications and national translational HBV consortia.
• Ideal stepping stone for candidates aiming for PhD training or biomedical research careers.