Senior Scientist Phage Display

CK Group; Cambridgeshire and Peterborough; On-site; GBP 40,000 - 65,000; Full time

Job summary

A leading pharmaceutical company in Cambridge is seeking a Senior Scientist for their Protein Binder Discovery team. The successful candidate will apply phage display technology for selecting protein binders against therapeutic membrane protein targets, contributing to drug discovery efforts. The ideal applicant has a PhD or MSc/MRes with significant experience in phage display and strong molecular biology skills.

Qualifications

• At least 3 years of experience in phage display campaigns.
• Theoretical and practical expertise in phage display technologies.
• Experience with phage antibody libraries.

Responsibilities

• Employ phage display technology to select protein binders.
• Screen and validate hits using high-throughput assays.
• Assay development for challenging targets.

Skills

Phage display technology

Molecular biology proficiency

Problem-solving skills

Interpersonal skills

Education

PhD or MSc/MRes in a relevant area of biology

Job description

Overview

CK Group are working in partnership with Nxera Pharma UK Limited (formerly Sosei Heptares) to recruit a lab-based Senior Scientist position in the Protein Binder Discovery team based in Granta Park, Cambridge.

The Role

We are searching for an experienced phage display scientist to join the Protein Binders team, part of our Platform Technology division at Nxera Pharma. The successful candidate will use phage display expertise to identify and characterise protein binders against therapeutic membrane protein targets to enable structure determination and drug discovery efforts. The candidate will work in interdisciplinary teams in a project-centric fashion, with the aim of accelerating the development of life-changing medicines.

Responsibilities

• Employing phage display technology to select protein binders against membrane protein targets
• Screening and validating hits using high-throughput assays e.g. ELISA formats, BLI, cell binding assays
• Assay development for challenging targets
• Subcloning of plasmid constructs for expression and protein engineering of antibody frameworks
• Biophysical evaluation of VHH hits
• Sharing your expertise, insights, and ideas with the team, and department to positively influence project success
• Lab management to ensure equipment is regularly maintained and consumables organised efficiently
• Effective management of large datasets formulated for ease of sharing data

Requirements

• PhD (or MSc/MRes with equivalent lab experience) in a relevant area of biology with at least 3-years experience carrying out phage display campaigns
• Theoretical and practical expertise in phage display technologies and selection techniques
• Experience working with phage antibody libraries and preferably VHH display
• Strong and evidenced molecular biology proficiency
• Demonstrable expertise in protein-protein interaction screening techniques
• Dynamic, analytical thinker with good problem-solving skills
• Have strong interpersonal skills and interact effectively with scientists across disciplines to generate timely and informative data.

Desirables

• Measuring protein binder affinity using either BLI or SPR
• Affinity maturation
• Library build (either affinity maturation or immunised, naïve or synthetic libraries)
• Working with membrane proteins (in particular GPCRs)
• Computational expertise in protein binder design

Apply

Please quote job reference 152 779 in all correspondence.