Principal Scientist

ZipRecruiter; Oxford; Hybrid; GBP 40,000 - 60,000; Full time

Job summary

An innovative biotech start-up in Oxford seeks an experienced Scientist at either Senior or Principal level. The role involves leading T-cell engagers validation and supports the development of TCR engineering processes. Candidates should possess a PhD in a relevant field, with experience in in vivo and in vitro validation of T-cell engagers and contribute to cutting-edge cancer treatment solutions. Home working is an option based on project demands.

Benefits

Competitive salary

Option for home working

Stock options

Qualifications

• Strong laboratory experience in academia and industry.
• Experience in in vivo and in vitro validation of T-cell engagers (TCEs).
• Experience with Investigational New Drug (IND) enabling/approval is essential.
• Expertise in cell and immunological assays and knowledge of cloning and PCR.
• Strong background in protein and biophysical characterization.

Responsibilities

• Perform high-throughput TCR display methods by purifying recombinant TCRs.
• Carry out protein characterization including expression, purification, and biophysical analysis.
• Design and characterize TCRs for disease targets.
• Oversee lab protocols and technical documents.
• Be hands-on in the lab and manage tissue culture preparations.

Skills

Data analysis using software R

Education

PhD in biochemistry, immunology, or cell biology

Tools

Flow cytometry

ELISA

Job description

Job Description

CK Group is recruiting for an experienced and dynamic Scientist, at either Senior or Principal level, to join an early-stage biotechnology start-up based in Oxford on a permanent basis.

The Company:

Our client is an early-stage biotechnology start-up combining artificial intelligence (AI) and advanced high-throughput TCR screening techniques to revolutionise the treatment of solid cancers.

Location:

Oxford.

The Role:

To lead the in vivo and in vitro validation of T-cell engagers, and help drive the development of TCR engineering and processes.

Responsibilities:

• Perform high-throughput TCR display methods by purifying recombinant TCRs.
• Carry out protein characterisation (expression, purification, and biophysical analysis).
• Design and characterise TCRs for disease targets.
• Oversee lab protocols and technical documents.
• Be hands-on in the lab and manage tissue culture preparations.

Skills:

Skills in data analysis (using software R) for Next Gen Sequencing analysis are desirable.

Your Background:

• PhD qualified in biochemistry, immunology, or cell biology, with strong laboratory experience (academia and industry).
• Experience in in vivo and in vitro validation of T-cell engagers (TCEs).
• Experience with Investigational New Drug (IND) enabling/approval is ESSENTIAL.
• Expertise in cell and immunological assays (flow cytometry, ELISA) with knowledge of cloning and PCR.
• Strong background in protein and biophysical characterisation.

Benefits:

Competitive salary, option for home working (as per project demands), stock options.

Apply:

It is essential that applicants hold entitlement to work in the UK. Please quote the job reference (Apply online only) in all correspondence.

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