Postdoctoral Scientist - Cell Biology - Dr Ramanujan Hegde - LMB 2749

MRC Laboratory of Molecular Biology (LMB); Cambridgeshire and Peterborough; On-site; GBP 36,000 - 43,000; Full time

Job summary

A leading research institute in the UK is seeking two Postdoctoral Scientists to conduct innovative research on molecular mechanisms related to protein maturation. Candidates should have a PhD or be nearing completion, with strong expertise in protein purification and characterization. Successful applicants will have the chance to work on advanced projects in a collaborative environment, and benefit from substantial professional development opportunities, including competitive benefits and a supportive workplace culture.

Benefits

40.5 days holiday per annum

Defined benefit pension scheme

Staff restaurant

Cycle enclosures and parking

Employee discount scheme

Training and development opportunities

Qualifications

• High level of proficiency with protein purification and biophysical characterization.
• Experience with structure determination and analysis of proteins.
• Knowledge of the biology of the endoplasmic reticulum and chaperones.

Responsibilities

• Investigate protein quality control during assembly of proteins.
• Research membrane proteins' insertion and assembly processes.

Skills

Protein purification

Biophysical characterization

Cell biological assays

Mammalian cell culture

In vitro reconstitution

Education

PhD or nearing completion in relevant subjects

Job description

Postdoctoral Scientist
Salary £42,694 per annum
Fixed Term, 3 Years
MRC Laboratory of Molecular Biology, Cambridge, UK

Applications are invited for two Postdoctoral Scientist positions in the laboratory of Dr Ramanujan Hegde at the MRC Laboratory of Molecular Biology (LMB). To work on one of two projects within a programme aimed at understanding the molecular mechanisms of protein maturation, quality control, and protein aggregation diseases.

Project 1: to investigate the process of protein quality control during the assembly of proteins and protein complexes.

Project 2: to investigate the process by which complex membrane proteins are inserted and assembled correctly at the endoplasmic reticulum.

Applicants should have a PhD or be due to complete a PhD within six months, in a subject relevant to the envisioned projects such as biochemistry, structural biology, or biophysics. Essential skills for both projects are a high level of proficiency with protein purification and biophysical characterization and experience with structure determination of proteins and analysis and interpretation of protein structures.

Additionally for project 1, experience with cell biological assays, including mammalian cell culture and genetic manipulation and a knowledge of the biology of the endoplasmic reticulum and chaperones is required. For project 2, experience with in vitro reconstitution of protein function using biochemical and biophysical assays is a requirement.

These are three-year training and development positions suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

LMB has a collaborative working culture and state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. We have a staff restaurant with roof terrace and access to a Campus nursery and sports and social facilities. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications. Further information about the benefits available can be found at http://www.discover.ukri.org/benefits-of-working-at-ukri.

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.

Closing date: 5th January 2025

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; [e-mail].