Medical Director

Advanced Clinical; Sheffield; On-site; GBP 100,000 - 150,000; Full time

Job summary

A leading clinical development company is seeking a Senior Medical Director with extensive experience in ophthalmology. This high-impact role involves leading global clinical development programs, overseeing trial design, and providing scientific leadership. Candidates must have an MD, MD/PhD, or PhD, with proven experience in ophthalmology clinical development. Strong expertise in regulatory requirements and a capacity to influence stakeholders is essential for success in this strategic position, ensuring programs remain scientifically robust and competitive.

Qualifications

• MD, MD/PhD, or PhD is mandatory.
• Proven experience in ophthalmology clinical development, ideally including retinal diseases.
• Strong expertise in clinical trial design, GCP, regulatory requirements, and medical monitoring.

Responsibilities

• Lead global clinical development programs in ophthalmology.
• Provide medical and scientific leadership across trial design and execution.
• Oversee medical data review and safety monitoring.

Skills

Ophthalmology experience

Clinical trial design

Safety oversight

Pharmacovigilance

Data review

Stakeholder influence

Education

MD, MD/PhD, or PhD

Tools

OCT

Fundus photography

Job description

Medical Director, Ophthalmology (Clinical Development)

MD or PhD required | Ophthalmology experience essential

We are seeking a senior Medical Director with deep ophthalmology experience to lead global clinical development programs in this space. This is a high-impact leadership role responsible for defining and executing clinical strategy across ophthalmology studies, from first-in-human through Phase 3.

You will provide medical and scientific leadership across trial design and execution, including protocol development, feasibility, site strategy, enrolment planning, and safety oversight. Acting as the primary medical authority, you will partner closely with cross-functional teams, investigators, and external experts, offering guidance on disease biology, benefit–risk assessment, and regulatory standards.

This role plays a key part in medical data review, safety monitoring, and contributions to regulatory submissions and interactions with health authorities. You will also build and maintain strong relationships with key opinion leaders, ensuring programs remain scientifically robust and competitive within the ophthalmology landscape.

Required Experience and Background

• MD, MD / PhD, or PhD is mandatory (ophthalmology degree not required, but ophthalmology experience is essential )
• Proven experience in ophthalmology clinical development , ideally including retinal or inherited retinal diseases
• Background in pharma or biotech in roles such as Medical Director, Associate Medical Director, or Clinical Scientist
• Strong expertise in clinical trial design, GCP, regulatory requirements, and medical monitoring
• Experience with safety oversight, pharmacovigilance, and data review
• Familiarity with ophthalmic assessments and imaging (e.g., OCT, fundus photography) is highly desirable
• Ability to lead scientific discussions, influence stakeholders, and operate strategically in a fast-moving environment