Director, Quantitative Clinical Pharmacologist

ENGINEERINGUK; Greater London; On-site; GBP 135,000 - 226,000; Full time

Job summary

A leading biopharma company in the UK is seeking a Director, Quantitative Clinical Pharmacologist to lead innovative approaches in drug development and lifecycle management within the infectious disease area. Candidates should possess a PhD or equivalent, 5+ years of relevant experience, and a strong background in clinical pharmacokinetics. The role demands excellent problem-solving skills and the ability to communicate effectively. A hybrid work environment is offered, focusing on cross-functional collaboration and scientific innovation.

Benefits

Health care benefits

Retirement benefits

Annual bonus

Paid holidays and vacation

Qualifications

• Advanced Degree in Life sciences required.
• 5+ years in clinical pharmacokinetics with significant reporting experience.
• 2+ years in PK/PD principles and applications in the pharmaceutical industry.
• Experience with regulatory submission documents necessary.

Responsibilities

• Design clinical development programs and registration packages.
• Utilize PK and PD principles in drug development.
• Develop mathematical models to understand disease and drug effects.
• Conduct simulations for trial design performance assessment.

Skills

Clinical Pharmacokinetics

Modeling & Simulation

Pharmacodynamics

Team Collaboration

Problem-solving

Education

PhD, PharmD or MD

Tools

NONMEM

R

WINNONLIN

SAS

MATLAB

Job description

Director, Quantitative Clinical Pharmacologist

Site Name: Upper Providence, GSK HQ, Stevenage, Waltham
Posted Date: Dec 5 2025

GSK has an inspiring ambition: by uniting science, technology and talent we aim to positively impact the health of 2.5 billion people over the next ten years. We will get ahead of disease together with our R&D approach of focusing on the science of the immune system, human genetics and advanced technologies, such as functional genomics and AI/ML.

Job Purpose

We have an exciting opportunity at GSK for a highly innovative Quantitative Clinical Pharmacologist to join our team supporting infectious disease area. GSK provides a supportive environment for scientists who are aspiring to learn, to contribute and to make impact on business decisions through innovation, expertise, and influence.

You will be part of a science‑driven group delivering clinical pharmacology and modelling & simulation excellence to research and development programs. You'll have the opportunity to work on both small molecules and biologics in the Vaccines and Infectious Disease therapeutic area. Responsibilities generally commence post‑candidate selection with accountability occurring from approximately 6 months prior to FTIH through to life‑cycle management.

Key Responsibilities

• Contribute, as a member of a multi‑disciplinary team, to the design of an efficient clinical development program, robust registration package and support life‑cycle management of an asset
• Provide optimal application of Clinical Pharmacokinetic (PK), Pharmacodynamic (PD), and Modeling & Simulation (MS) principles towards efficient drug development, risk management, and registration of compounds
• Play a central role in predicting human dose range, characterising exposure‑response relationship and justifying dose recommendations for special populations
• Develop mathematical models to understand disease, its progression, and drug pharmacodynamics and pharmacokinetics; conduct meta‑analyses as appropriate to generate knowledge through data re‑use; conduct simulations to assess trial design performance
• Present strategy and discuss outcome of model‑based approaches via interactions with governance boards and regulatory agencies
• Provide a thorough understanding and ability to apply appropriate FDA and ICH guidelines in the design of clinical studies and drug development strategy
• Promote model‑informed drug discovery and development (MID3) through external collaboration, journal publication and conference presentation
• Design and interpret clinical pharmacology studies to evaluate potential effects of intrinsic and extrinsic factors on pharmacokinetics and pharmacodynamics
• Identify opportunities to utilise in‑silico PBPK approaches to replace in‑vivo clinical studies to explore the impact of DDI and special populations on PK where appropriate
• Write sections of drug development and registration documents such as clinical trial protocols and reports, clinical investigator brochures and regulatory submission packages
• Learn and apply emerging modelling and simulation methodologies with a view to enhance clinical programme efficiency and investment decision quality; collaborate with external field‑leading teams for methodology application
• Innovate through working effectively with colleagues in the department and other matrix team members, including statisticians, biologists, physicians and drug metabolism scientists

Basic Qualifications

• Advanced Degree in Life science such as PhD, PharmD or MD to enable a successful career in quantitative clinical pharmacology in pharmaceutical research and development
• 5 years+ experience in clinical pharmacokinetics, modelling & simulation and model‑informed drug development including designing, analysing and reporting clinical studies
• 2 years+ experience of pharmacokinetic and pharmacodynamic principles and commonly applied models through previous projects in pharmaceutical industry roles or equivalent
• 2 years+ experience working with common tools for quantitative clinical pharmacology such as NONMEM, R, WINNONLIN, SIMCYP, SAS and MATLAB through previous hands‑on projects
• 1 year+ experience with regulatory submission documents such as CTAs, INDs, NDAs, MAAs and BLAs through direct involvement in regulatory submission activities in previous roles
• 1 year+ experience through previous roles in applying appropriate FDA and ICH guidelines in the design of clinical development plans and studies

Preferred Qualifications

• Knowledge of or ability to quickly learn the mechanism, endpoints, progression and treatments of diseases in infectious disease and other relevant therapy areas
• Ability to communicate clearly and succinctly with the audience in mind, both orally and in writing
• Ability to build effective collaboration while taking personal accountability for delivery of quantitative clinical pharmacology results
• Sound judgement, analytical mindset and problem‑solving skills
• Ability to effectively multi‑task and deliver results on time

Benefits

Hybrid location. Annual base salary ranges $180,675 to $301,125 for new hires in Waltham, Cambridge, MA, Rockville, MD and San Francisco, CA, taking into account location, skills, experience, education level and market rate for the role. Positions also offer an annual bonus and eligibility to participate in our share‑based long‑term incentive program dependent on the level of the role. Benefits include health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together, so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make – so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1‑877‑694‑7547 (US Toll Free) or [phone] (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Company

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make – so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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