Researcher in neuro-oncology and metabolic analysis M/F

CNRS; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading research institution in France seeks a postdoctoral researcher to work on characterizing myelin's role in glioblastoma development. Responsibilities include culturing patient-derived cells and conducting in vivo experiments as part of a collaborative project. Candidates should possess expertise in neuroscience and cell culture techniques, with strong proficiency in English required. The position aims to foster a stimulating scientific environment at the intersection of cancer research and bioinformatics.

Prestations

Additional training opportunities

Qualifications

• Proficiency in spoken and written English is essential.
• Knowledge of neuro-oncology is a plus.
• Experience in metabolic analyses is desirable.

Responsabilités

• Establish culturing techniques for murine oligodendrocytes.
• Carry out genetic and pharmacological manipulations of human cancer cells.
• Conduct animal experiments to study lipid roles in glioblastoma invasion.
• Monitor relevant scientific literature and present findings at meetings.

Connaissances

Expertise in neuroscience

Cellular and molecular biology expertise

Strong proficiency in human cell culture techniques

Language proficiency in English

Description du poste

Organisation/Company CNRS Department Institut de Biochimie et Génétique Cellulaires Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Application Deadline 4 Feb 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Mar 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The postdoctoral researcher will work on characterizing the role of myelin in the development of glioblastomas. The postdoc will use in vitro approaches to culture patient-derived cells with oligodendrocytes and will also be required to carry out or assist with in vivo experiments. This work will be conducted as part of a competitive grant obtained by a consortium bringing together French teams with complementary neuro‑oncology models, tools, and expertise, including cancer cell metabolism and computational biology. This project is also part of an international collaboration with a laboratory at the DKFZ in Heidelberg, Germany.

Main activities

• Establishing the technique for culturing murine oligodendrocytes and co‑culturing them with glioblastoma cells.
• Carrying out experimental assays required for the project (genetic and pharmacological manipulation of human cancer cells, cell biology experiments, biochemistry, metabolic profiling, measurement of metabolic or electric activities via probes or MEA system, and in vitro imaging using confocal microscopy).
• Animal experiment to decipher the most important lipids during glioblastoma invasion.
• Monitoring the scientific literature relevant to the project.
• Presenting results at weekly laboratory meetings and at national and international scientific meetings.

Secondary activities

• Interacting with other team members and collaborators.
• Participating in in‑vivo experiments (access to immunodeficient animals and neurosurgery).
• Taking part in the laboratory's collective activities (e.g., meetings, seminars).

This position is part of the INCA PLBIO project, which brings together experts in neuro‑oncology, lipidomics analysis, and bioinformatics to understand the functional role of lipids in the development of glioblastomas. The project is embedded within these activities, ensuring a stimulating scientific environment at the interface of cancer research, neuroscience, and bioinformatics. The postdoctoral researcher will join the Glioblastoma Metabolism team at IBGC (CNRS, Bordeaux), led by Dr. Thomas Daubon, and will work in close collaboration with the consortium's partners, including the teams of Dr. Lucie Brisson (Bordeaux), Dr. Justine Bertrand‑Michel (Toulouse), and Dr. Marie Beurton‑Aimar (Bordeaux).

Main skills

• Expertise in neuroscience, cellular and molecular biology, and metabolic analyses.
• Knowledge of neuro‑oncology would be an asset.
• Familiarity with the functioning of cerebral metabolic systems or glioblastoma biology will be appreciated.
• Language skills: proficiency in spoken and written English is essential in the international group.

Skills

• Strong proficiency in human cell culture techniques, microscopy, and solid knowledge of metabolic fluxes, metabolomic and transcriptomic analyses.
• Ability to quickly adapt to new methodologies.
• Proficiency in using computer tools and software dedicated to data processing.

Personal qualities

• The postdoctoral researcher must be motivated, rigorous, well‑organized, and able to work independently.

Additional training opportunities

Additional training opportunities aimed at enriching the postdoctoral researcher's knowledge may be offered during the fixed‑term contract.