Researcher in biology, life sciences M/F

CNRS; France; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

A leading national research organization in France seeks a Research Engineer for developing immunocompetent 3D models of the human nasal mucosa. This role involves cell isolation, 3D model construction, and viral strain analysis, contributing to the understanding of immune responses in respiratory infections. Ideal candidates should have a background in molecular biology, tissue engineering, and proficiency in English. The position offers a full-time contract and supports private health insurance and public transport costs.

Prestations

Contribution to private health insurance

Covered meals at the administrative restaurant

Public transportation support

Qualifications

• Prior knowledge and experience in molecular biology, primary human cell culture, immunology, and tissue engineering.
• Knowledge of molecular biology techniques like PCR and qPCR.
• Proficiency in English at level B1 according to the Common European Framework of Reference for Languages.
• Ability to write manuscripts and analyze relevant literature.

Responsabilités

• Isolation, culture, and characterization of primary cells from human nasal mucosa biological samples.
• Construction of 3D models of nasal mucosa.
• Amplification of viral strains (influenza) and infection of 3D models in a BSL2 laboratory.
• Analysis of gene expression by quantitative RT-PCR.
• Immunolabeling on frozen and paraffin sections.
• Preparing manuscripts for publication in international journals.

Connaissances

Molecular biology

Primary human cell culture

Immunology

Tissue engineering

PCR

qPCR

English proficiency (B1)

Manuscript writing

Literature analysis

Autonomy in work analysis

Supervision of interns

Description du poste

Organisation/Company CNRS Department Immunologie, Immunopathologie et Chimie Thérapeutique Research Field Pharmacological sciences Engineering Technology Researcher Profile Recognised Researcher (R2) Country France Application Deadline 19 Dec 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The human nasal mucosa is the first site of contact for airborne viral infections. Although various in vitro models exist for studying respiratory viral infections, the composition of these in vitro models does not reflect the complexity required to physiologically reproduce tissue architecture and immune responses. To overcome these limitations, we are developing immunocompetent 3D models of the human nasal mucosa, enabling the study of innate immune responses in the context of influenza virus infection.

• Isolation, culture, and characterization of primary cells from human nasal mucosa biological samples.
• Construction of 3D models of nasal mucosa.
• Amplification of viral strains (influenza) and infection of 3D models in a BSL2 laboratory.
• Analysis of gene expression by quantitative RT-PCR.
• Immunolabeling on frozen and paraffin sections
• Preparing manuscripts for publication in international journals.

The successful candidate will join the CNRS UPR3572/I2CT laboratory at the Institute of Molecular and Cellular Biology (IBMC) located on the central campus of the University of Strasbourg, France.

• A major player in fundamental research worldwide, the French National Center for Scientific Research (CNRS) is the only French organization active in all scientific fields. Its unique position as a multi‑specialist allows it to combine different scientific disciplines to shed light on and understand the challenges of the contemporary world, in collaboration with public and socio‑economic actors.
• The CNRS UPR3572/I2CT “Immunology, Immunopathology, and Therapeutic Chemistry” laboratory focuses on the molecular and cellular foundations of the immune response and its dysfunctions with the aim of defining new therapeutic avenues for targeted immuno‑intervention in the treatment of autoimmune, tumor, and viral diseases. It has state‑of‑the‑art equipment in cytometry, microscopy, and transcriptomics.
• The “Interactions of the Immune System with its Microenvironment” group studies the functional relevance of interactions between innate and adaptive immune cells and their immediate environment (mesenchymal cells, endothelial cells, epithelial cells, and neurons) in health and disease. This project will be led by Dr. Vincent Flacher (CNRS Research Director). The work is based on a collaboration with the otorhinolaryngology department at Hautepierre University Hospital (Prof. C Debry, IHU Strasbourg) and Dr. R Smyth's team (CNRS UPR9002/ARN, Strasbourg).

• Prior knowledge and experience in molecular biology, primary human cell culture, immunology, tissue engineering.
• Knowledge of molecular biology techniques (PCR, qPCR)
• English language proficiency at level B1 according to the Common European Framework of Reference for Languages; B1 corresponds to the level of autonomy
• Ability to write manuscripts
• Ability to read and analyze relevant literature in the field.
• Autonomy, ability to critically analyze one's own work and that of colleagues, making constructive suggestions.
• Ability to supervise interns and students

Additional comments

Working hours: 38.5 hours per week, Monday to Friday, daytime hours.
The Institute is located in the heart of the University of Strasbourg's central campus, accessible by bus and tram. The CNRS contributes to the cost of private health insurance and public transportation. An administrative restaurant is available on campus. Meals are covered by the CNRS.