Postdoctoral position in fast MAS solid-state NMR (M/F)

CNRS; France; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A prominent research organization in France seeks a Researcher to focus on NMR methodology related to viral membrane proteins. This temporary position starts in February 2026 and involves conducting advanced NMR analyses and collaborating with a dedicated team. The ideal candidate should hold a PhD in a relevant field and have experience in NMR spectroscopy. The successful candidate will enjoy an engaging work environment and access to extensive research facilities.

Qualifications

• PhD in relevant discipline with experience in NMR spectroscopy.
• Strong interest in interdisciplinary research.
• Ability to prepare proteins and analyze data.

Responsabilités

• Implement proton-detected fast MAS solid-state NMR methods.
• Analyze samples using solid-state NMR and biophysical approaches.
• Collaborate with team members on larger project aspects.

Connaissances

Experience in solution and/or solid-state NMR spectroscopy

Strong interest in interdisciplinary work on viral proteins

Protein preparation

Data interpretation

Formation

PhD in chemistry, biochemistry, or biophysics

Description du poste

Organisation/Company CNRS Department Microbiologie Moléculaire et Biochimie Structurale Research Field Chemistry » Biochemistry Physics » Biophysics Biological sciences » Biological engineering Researcher Profile First Stage Researcher (R1) Country France Application Deadline 3 Dec 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The project aims to implement proton-detected fast MAS solid-state NMR methods to investigate the structure of viral membrane proteins and their interactions with nucleic acids.
The protein solid-state NMR team focuses on the study of virulence factors in emerging infectious diseases, with the goal of better understanding molecular mechanisms of infection.
Our current work centers on Buniaviricetes, three of which are listed among the World Health Organization (WHO) top-ten priority pathogens, including the highly deadly Crimean-Congo hemorrhagic fever virus (CCHFV).
The successful candidate will primarily focus on NMR methodology, comprising three major points: the full use of the selective labeling potential of cell-free protein synthesis, in the context of combinatorial labeling approaches for sequential assignments; the introduction of new isotopes into protein NMR; and the optimal implementation of intermolecular polarization transfer schemes. S/he will also produce samples following well-established protocols, mainly based on cell-free synthesis, but also bacterial expression. S/he will analyze them by solid-state NMR, potentially complemented by other biophysical approaches and solution NMR. The candidate will work closely with other team members involved in complementary aspects of this larger project.
The project is supported by outstanding funding over several years (https://www.fondationbs.org/notre-communaute/laureats-et-projets/anja-b… ). More information about the team's research projects can be found on the group webpage: https://mmsb.cnrs.fr/en/team/protein-solid-state-nmr/ .
The position is available starting January 2026, with later being possible. The position is initially funded for one year, with possible extensions up to three years.

• NMR measurements (0.7 mm 1H-detected MAS NMR) and implementation of advanced approaches
• NMR spectra analysis (CCPN) and data interpretation
• Protein preparation using cell-free/bacterial protein synthesis, design of dedicated labeling variants
• Biophysical characterization of the proteins and their interactions

The protein solid-state NMR laboratory is located within the Molecular Microbiology and Structural Biochemistry (MMSB) unit in the Lyon Gerland Bioscience Campus, regrouping major institutions in virology such as the CIRI and the Lyon BSL4 lab. The campus is located in close proximity to the city center and with convenient access to public transportation, including the subway, tram, and cycle paths. The lab has extensive spectrometer time at the High Field NMR Center of Lyon (CRMN), on several NMR spectrometers (500 MHz, 600 MHz, 800 MHz and 1000 MHz) and fast-MAS probes (2 x 0.7 mm probes, 1.3 mm probe, …), and higher fields at national facilities and through collaboration. The MMSB is fully equipped with a wet lab for protein expression and purification. Access to a range of biophysical platforms (ITC, SEC-MALLS, nanoDSF, mass spectrometry …) is given at the MMSB. We offer a welcoming environment with a friendly and satisfying working atmosphere.

Research Field Biological sciences » Biological engineering Years of Research Experience None

Additional Information

Eligibility criteria

The ideal candidate holds a PhD in chemistry, biochemistry or biophysics (or related discipline), and a strong interest in interdisciplinary work on (viral) proteins. S/he will have experience in solution- and/or solid-state NMR spectroscopy.