Postdoc in DNA Origami Molecular Tools to Investigate Biological Systems

Université Paris Cité; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading research institution in France is seeking a highly motivated postdoctoral researcher to join the CiTCoM lab. This full-time position focuses on the design and implementation of new molecular tools using DNA nanotechnology for biological studies. The ideal candidate will have a PhD and strong expertise in related fields. The position starts on December 1, 2025, and offers a unique opportunity for cross-disciplinary research.

Qualifications

• Strong expertise in DNA nanotechnology, Biophysics, Biochemistry, or Structural Biology.
• Experience with preparation of self-assembled DNA nanostructures.
• Good command of English.

Responsabilités

• Develop new DNA nanostructures for molecular imaging.
• Create DNA nano-machines and nano-robots for drug delivery.

Connaissances

DNA nanotechnology

Biophysics

Biochemistry

Structural Biology

Cryo-EM

DNA origami design

Formation

PhD in a relevant field

Outils

CADnano

Description du poste

Biological sciences >> Biological engineering

Chemistry >> Physical chemistry

Organisation/Company Université Paris Cité Research Field Biological sciences >> Biological engineering Physics >> Biophysics Chemistry >> Biochemistry Chemistry >> Physical chemistry Engineering >> Design engineering Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country France Application Deadline 30 Nov 2025 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 38 Offer Starting Date 1 Dec 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We are seeking a highly motivated postdoctoral researcher with an interest in cross-disciplinary research to join our CiTCoM lab (Cibles Thérapeutiques et Conception de Médicaments), localized at Université Paris Cité, on the Faculty of pharmacy in Paris, France. This is a full-time 24-month position involving the design, charaterization, and implementation of new molecular tools based on DNA nanotechnology for the study of biological systems. The project is funded by the French National Research Agency and will be carried out under the supervision of Nesrine Aissaoui.

Project description

Our laboratory develops and exploits the modularity and the high degree of addressability of self-assembled DNA nanostructures as a biosynthetic tool to probe fundamental aspects of biology. The recruited postdoc will develop two main projects:

• (1) the creation of new-based DNA nanostructures as a molecular template to hold proteins to facilitate molecular imaging by single-particle Cryo-Electron Microscopy (Cryo-EM); and
• (2) the development of DNA-based nano-machines and nano-robots as a drug delivery vehicles.

Candidate profile

We are looking a highly enthusiastic motivated recently graduated PhD with a strong expertise in DNA nanotechnology, Biophysics, Biochemistry, or Structural Biology, and a strong interest in applying this knowledge to biology. Experience in the field of Cryo-EM or in DNA origami design and visualization tools (e.g. CADnano) is highly desirable.

The position is expected to start in December 1, 2025, as a 24 months full-time appointment.

Contact

Candidates are invited to submit a complete CV with a list of publication, a motivation letter, and the name of two references to the main investigator:
Dr. Nesrine Aissaoui
[e-mail]
Phone: [phone]
CiTCoM - UMR 8038 CNRS (https://www.citcom.cnrs.fr/ )

Where to apply

E-mail [e-mail]

Requirements

Research Field Physics >> Biophysics Education Level PhD or equivalent

Research Field Chemistry >> Physical chemistry Education Level PhD or equivalent

Research Field Biological sciences >> Biological engineering Education Level PhD or equivalent

Skills/Qualifications

Highly enthusiastic motivated recently graduated PhD with a strong expertise in DNA nanotechnology, Biophysics, Biochemistry, or Structural Biology, and a strong interest in applying this knowledge to biology.

Specific Requirements

Experience with preparation of self-assembled DNA nanostructures and/or hybrid DNA nanostructures.

Languages ENGLISH Level Good

Internal Application form(s) needed

Postdoc DNA origami_Tools for Cryo-EM and biophysics 2025.pdf