Intracellular Persister Biology

CIRI-Centre International de recherche en Infectiologie - Université Lyon 1 - CNRS UMR5308; France; Sur place; EUR 35 000 - 40 000; Plein temps

Résumé du poste

A renowned research institute in France seeks a dedicated postdoctoral scientist to investigate bacterial persisters and their emergence within macrophages. The successful candidate will engage in innovative projects at the intersection of cell and molecular biology, utilizing cutting-edge technologies. Candidates should hold a PhD in cell biology with a strong publication record. Team spirit and English proficiency are essential. This position is based in Lyon, France.

Qualifications

• PhD degree in cell biology required.
• Strong publication record relative to experience.
• Experience in macrophage biology or immune cell research is a plus.

Responsabilités

• Investigate how bacterial persisters arise within macrophages.
• Develop projects at the interface of cell biology and microbiology.
• Pursue independent research ideas.

Connaissances

Research in macrophage biology

Cell biology

Excellent communication skills

Formation

PhD in cell biology

Description du poste

Organisation/Company CIRI-Centre International de recherche en Infectiologie - Université Lyon 1 - CNRS UMR5308 Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 27 Dec 2025 - 22:00 (UTC) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Many pathogens are difficult to eradicate, even in the absence of genetically encoded antimicrobial resistance mechanisms and despite remaining susceptible to antibiotics in vitro. A subset of clonal bacteria can transiently withstand antibiotic treatment; these cells are known as antibiotic persisters . Increasing evidence highlights the pivotal role of the host cell environment in driving persister emergence. We are seeking a highly motivated postdoctoral scientist to investigate how bacterial persisters arise within macrophages. The successful candidate will develop innovative projects at the interface of cell biology, microbiology, and molecular biology, while leveraging cutting-edge single-cell technologies and multi-omics approaches. Candidates will also be encouraged to pursue independent ideas as they progress toward becoming an independent scientist.

At CIRI, the Persistence and single-cell dynamics of respiratory pathogens Lab led by Nicolas Personnic explores how heterogeneity, across scales, is generated and how it allows pathogens to evade antibiotic clearance. We welcome applications from individuals driven to decipher how heterogeneity impacts infection processes and persister biology, as well as those excited about pioneering new concepts and methods in quantitative single-cell biology. Candidates should hold a PhD degree in cell biology, with a strong publications record relative to their experience level. Experience in macrophage biology or other immune cell research is considered a plus. Team spirit is essential as well as an excellent oral and written communication skills in English.Scientists eligible for international postdoctoral mobility programs (eg. marie-sklodowska-curie-actions, …) supporting research in France are strongly encouraged to apply.

Additional Information

Work Location(s)

Number of offers available 1 Company/Institute CIRI-Centre International de recherche en Infectiologie - Université Lyon 1 - CNRS UMR5308 Country France City Lyon Geofield