Senior Scientist (Protein Analysis unit)

CHUGAI PHARMABODY RESEARCH PTE. LTD.; Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A biotechnology firm in Singapore is looking for a Senior Scientist to lead antibody characterization. This role requires deep expertise in protein analysis, conducting analyses from high-throughput screening to developability assessment. The ideal candidate will hold a Ph.D. and have experience in protein-protein interactions. Responsibilities include collaborating on projects and developing novel protein analysis technologies. Strong problem-solving skills and proficiency in English are essential.

Qualifications

• Ph.D. in Biophysics, Biochemistry, or a related scientific field with 0 - 2+ years experience.
• Strong expertise in protein-protein interaction analysis and monoclonal antibody drug discovery.
• Proficiency in spoken and written English.

Responsibilities

• Lead antibody binding affinity screening using SPR.
• Plan and conduct biophysical analyses of antibodies.
• Support projects from screening to developability assessment.

Skills

Protein-protein interaction analysis

Binding kinetic and affinity analysis

Physicochemical characterization of monoclonal antibodies

Problem-solving skills

Data analysis and visualization

Education

Ph.D. in a relevant field

Tools

SPR

BLI

GCI

Column chromatography

Biophysical characterization

Protein LC-MS

Job description

Senior Scientist, Protein Analysis

We are seeking a Senior Scientist with deep expertise in protein analysis to lead antibody characterization across discovery and optimization, from high-throughput screening through developability. Reporting to the Research Manager, you will drive assay development and data generation, collaborate closely with cross-functional teams, and contribute to novel protein analysis technology development. After initial training, you are expected to independently manage antibody analysis.

Key Responsibilities

• Lead antibody binding affinity screening using SPR.
• Plan and execute antibody/ligand binding analyses.
• Plan and conduct biophysical analyses to evaluate physicochemical properties of antibodies.
• Assess developability and manufacturability of antibody drug candidates.
• Support projects from high-throughput screening to late-stage developability assessment, collaborating with multidisciplinary teams to achieve project milestones.
• Contribute to the development and implementation of novel protein analysis technologies.

Required Qualifications

• Ph.D. in Biophysics, Biochemistry, Structural Biology, Biomedical Science, Chemical Biology, Biotechnology, Life Science, or Pharmaceutical Science, or a related scientific field with 0 - 2+ years of relevant industry or research experience, preferably in monoclonal antibody drug discovery.
• Strong expertise in protein-protein interaction analysis, binding kinetic and affinity analysis, physicochemical characterization of monoclonal antibodies.
• Hands-on experience in at least one of the following areas:
• Protein-protein interaction analysis (SPR, BLI, GCI)
• Column chromatography (ion-exchange, size-exclusion, reversed-phase)
• Biophysical characterization (DLS, DSC, solubility, viscosity, stability testing)
• Protein LC-MS analysis

• Ability to work in a fast-paced, collaborative environment
• Strong problem-solving skills and ability to work independently and in team settings
• Proficiency in spoken and written English.

The ideal candidate

• Demonstrates a strong passion for medical science and drug innovation.
• Capable of independently running and troubleshooting assays, optimizing methods, and adopting new technologies.
• Ensures data integrity, safety, compliance with SOPs.
• Skilled in data analysis, visualization, and clear communication to diverse audiences.
• Effective in planning, meeting deadlines, and collaborating across teams.

Application procedures

Interested applicants are invited to email their detailed resume, qualifications, availability, current and expected salary to: [e-mail]

For more information regarding our Company, you may refer to our website at: http://chugai-pharmabody.com/

We regret that only short-listed candidates will be notified