Jobs in Bolton, Grande-Bretagne

Consultant Call - DMPK (Peptide Therapeutics). Constructive Bio is seeking an experienced DMPK or PK/PD (preclinical pharmacology) consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now. We are open to short- or medium-term consulting arrangements.

• Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
• Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
• Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
• Analyse data, highlight risks, and recommend next steps to guide project teams.
• Benchmark against industry best practices and prepare input suitable for preclinical packages.
• Support vendor/CRO selection and study oversight.

• Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
• Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
• Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
• Strong communication skills to work with internal scientists and external partners.

• Experience of in vitro and in vivo safety and toxicology studies
• Knowledge and preparation of IND documents would be an advantage