Scientist - Target Discovery

JR United Kingdom; Cambridge; On-site; GBP 40,000 - 55,000; Full time

Job summary

A leading biotechnology company based in Cambridge is looking for a Scientist - Target Validation and Drug Screening. In this role, you will advance treatments for rare neurological disorders, including neuro-oncology. The ideal candidate holds a PhD in biological sciences with relevant industry experience and strong mammalian cell culture skills. You will also develop robust cell-based assays and integrate genetic perturbations to probe mechanisms.

Qualifications

• Proven industry experience in early target discovery and validation.
• Strong mammalian cell culture skills.
• Relevant degree in a biological science, ideally PhD.

Responsibilities

• Prioritize and triage drug and CRISPRi screen hits.
• Formulate testable hypotheses and design validation cascades.
• Develop and qualify robust cell-based assays.

Skills

High-content imaging

Flow cytometry

qPCR

Mammalian cell culture

Education

PhD in a biological science

Tools

CRISPR-based perturbation modalities

Cell-based assay development

Job description

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Our client, an innovative Biotechnology business, is seeking a Scientist - Target Validation and Drug Screening to join their team based in Cambridge. As the Scientist - Target Validation and Drug Screening, you will play a pivotal role in advancing treatments for rare neurological disorders, including neuro-oncology.

KEY DUTIES AND RESPONSIBILITIES:

Your duties as the Scientist - Target Validation and Drug Screening will be varied however the key duties and responsibilities are as follows:

1. Prioritise and triage drug and CRISPRi screen hits using literature, pathway analyses, public datasets, and internal context.

2. Formulate testable hypotheses and design validation cascades with clear go/no-go criteria and timelines. Execute orthogonal genetic validation.

3. Develop and qualify robust cell-based assays aligned to target biology and mechanism of action in 2D systems (3D preferred). Define and implement control strategies, plate and sample randomisation and batch-effect controls.

4. Integrate genetic and pharmacological perturbations to probe mechanism and pathway placement.

ROLE REQUIREMENTS:

To be successful in your application to this exciting role as the Scientist - Target Validation and Drug Screening we are looking to identify the following on your profile and past history:

1. Relevant degree in a biological science, ideally PhD, with proven industry experience in early target discovery and validation.

2. Proficiency in with high-content imaging, flow cytometry, qPCR or equivalent molecular assay. Strong mammalian cell culture skills.

3. A working knowledge and practical experience with CRISPR-based perturbation modalities and cell-based assay development.

Key Words:

Scientist / Target Validation / Drug Screening / CRISPR / Cell-based Assays / Biotechnology / Cambridge / Neuro-oncology / Genetic Epilepsies / Neuropathic Pain / Demyelinating Diseases

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements. HRS exclusively supports the Life Science sectors, combining recruitment expertise with scientific knowledge to help you advance your career.