Head of Clinical Pharmacology

RBW Consulting; Sheffield; On-site; GBP 80,000 - 100,000; Full time

Job summary

A leading biotech firm is seeking an accomplished Clinical Pharmacologist to shape strategy and guide execution across its development portfolio. Responsibilities include defining pharmacology strategies, overseeing first-in-human studies, and contributing to critical regulatory submissions. Candidates should possess an advanced degree and over 10 years of clinical pharmacology experience, with strong expertise in PK/PD modeling and leadership in cross-functional teams. This role offers a significant opportunity to influence key decisions in a dynamic environment.

Qualifications

• 10+ years in clinical pharmacology with small molecules.
• Proven leadership in global, cross-functional teams.
• Strong English communication and writing skills.

Responsibilities

• Define and implement clinical pharmacology strategies.
• Oversee first-in-human and drug–drug interaction studies.
• Contribute to IND, End-of-Phase 2, and NDA submissions.

Skills

Clinical pharmacology expertise

PK / PD modeling

Regulatory documentation

Leadership

Strong English communication

Education

Advanced degree (PharmD, PhD or equivalent)

Job description

RBW is seeking an accomplished Clinical Pharmacologist to play a pivotal role in shaping strategy and driving execution across a dynamic biotech’s development portfolio. In this high-impact position, you’ll be the leading authority on clinical pharmacology—developing innovative strategies, guiding study design, and integrating PK / PD and preclinical data into clinical development plans. You’ll influence critical decisions, oversee first-in-human and drug–drug interaction studies, and represent the company in regulatory interactions and external collaborations.

What You’ll Do

• Define and implement clinical pharmacology strategies across early and late-stage programs.
• Oversee first-in-human and drug–drug interaction studies, PK / PD modeling, and dose selection for Phase 2 / 3 trials.
• Contribute to IND, End-of-Phase 2, and NDA submissions, and represent the function in regulatory meetings.
• Work closely with preclinical, clinical, and CMC teams to optimise study design.

What We’re Looking For

• Advanced degree (PharmD, PhD or equivalent)
• 10+ years in clinical pharmacology with small molecules
• Expertise in PK / PD modeling, clinical pharmacology study design, and regulatory documentation
• Proven leadership in global, cross-functional teams
• Strong English communication and writing skills