Director of Clinical Biomarkers

Recursion; Oxford, City Of London; Hybrid; GBP 90,000 - 130,000; Full time

Job summary

A leading biopharmaceutical company is searching for a Director of Biomarkers to lead biomarker strategies across clinical programs. You will collaborate with cross-functional teams and manage the execution of biomarker assays. The ideal candidate has a PhD or MD, experience in biopharmaceuticals, and a strong understanding of clinical studies and biomarkers.

Benefits

Annual bonus

Equity compensation

Comprehensive benefits package

Qualifications

• 8+ years of biopharmaceutical industry experience with drug discovery.
• Extensive experience in clinical biomarkers and translational research.
• Strong understanding of regulatory requirements and best practices.

Responsibilities

• Lead the biomarker strategy and execution for assigned programs.
• Develop plans for pharmacodynamic and predictive biomarker assays.
• Manage CROs and vendors for assay development and validation.

Skills

Clinical biomarker understanding

Collaboration with cross-functional teams

Data analysis and interpretation

Problem-solving

Education

PhD, MD or equivalent in a relevant scientific discipline

Tools

Omics technology platforms

Job description

Overview

Locations: London, England; New York, New York; Oxford, England; Salt Lake City, Utah

The Impact You’ll Make

Recursion is at the forefront of reimagining drug discovery and development through broadening the funnel of potential targets, using technology and standardization to build connected data. Recursion has a strong and diverse pipeline that spans first-in-class and best-in-class assets across oncology and rare disease. As Director of Biomarkers, you will serve as the Biomarker lead on clinical program teams and will be responsible for delivering on fit-for-purpose biomarker strategies that include predictive and pharmacodynamic biomarker assays. You will leverage your deep understanding of the scientific, regulatory and operational aspects of biomarkers, to implement appropriate measurements that enable clinical decision making, and the development of safe and effective medicines to address unmet medical need.

Responsibilities

• Lead the overall biomarker strategy and execution for assigned program(s) in the Recursion portfolio by serving as the clinical biomarker lead on program/study teams.
• Develop plans collaboratively to deliver fit-for-purpose pharmacodynamic, predictive, prognostic and/or other biomarker assays to support decision making in early development. Work with discovery teams to support preclinical to clinical transitions of programs and align overall translational and biomarker strategies
• Partner with various research and clinical teams, including Clinical Operations, Stats, Data Management, Project Leadership, etc., to contribute to biomarker-related aspects of trial design and conduct, study documents (e.g. protocols, study reference manuals, study reports, INDs etc.), trial readouts/endpoints and regulatory interactions
• Actively manage CROs, vendors, suppliers and other groups for assay development and qualification/validation. Oversee the operational aspects of biomarker implementation, including sample logistics, data management, and coordination with internal teams and CROs.
• Stay current with emerging science and innovate with novel technologies and approaches to generate/analyze/apply data and derive insights on mechanisms, indications, combinations and patient selection/stratification.
• Present biomarker findings at key internal and external meetings

The Team You’ll Join

You will join the Development Sciences team, report to the Head of Clinical Biomarkers, and be part of the Clinical Development organization at Recursion. The Development Sciences team is a group of project-facing translational scientists that supports the transition of projects from discovery into clinical development and beyond. Core functions within this team include translational PK/PD modeling, clinical pharmacology, clinical bioanalysis and biomarkers. This is a collaborative group of scientists who work closely with discovery to ensure the progression of the right molecule at the right dose for the right patient, support IND filings, and ensure the continued implementation of translational strategies for projects in clinical development.

The Experience You’ll Need

• PhD, MD or equivalent in a relevant scientific discipline with 8+ years of biopharmaceutical industry experience with a solid understanding of drug discovery and early development
• Extensive experience in clinical biomarkers/diagnostics and/or translational research; strong understanding of clinical studies and working within cross-functional study/program teams contributing to biomarker relevant documents, plans, operations and workstreams
• Knowledge of regulatory requirements, best practices in applying translational science and biomarker assay development and validation to support global clinical trials
• Strong understanding of various technology platforms and datasets, including omics, for discovery, validation and implementation of biomarkers; familiarity with effectively engaging vendors and CROs providing services for biomarker assays
• Expertise in one or more of the following therapeutic areas: oncology, rare disease, immunology/inflammation
• Ability to think critically, strategically, practically to enable decision making and influence R&D teams and stakeholders; track record in problem solving, data analysis/interpretation and team science innovation

Working Location & Compensation

This position can be based at any of our offices in Salt Lake City / New York City / London / Oxford. Please note that we are a hybrid environment and ask that employees spend 50% of their time in the office. Relocation support can be provided for this role.

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is provided to help candidates assess fit.

You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package.

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Values

• We act boldly with integrity. We are unconstrained in our thinking, take calculated risks, and push boundaries, but never at the expense of ethics, science, or trust.
• We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up, speaking honestly, and taking action.
• We learn actively and adapt rapidly. Progress comes from doing. We experiment, test, and refine, embracing iteration over perfection.
• We move with urgency because patients are waiting. Speed isn’t about rushing but about moving the needle every day.
• We take ownership and accountability. Through ownership and accountability, we enable trust and autonomy—leaders take accountability for decisive action, and teams own outcomes together.
• We are One Recursion. True cross-functional collaboration is about trust, clarity, humility, and impact. Through sharing, we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at Recursion. They are the character and personality of the company demonstrated through how we communicate, support one another, spend our time, make decisions, and celebrate collectively.

More About Recursion

Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously generate one of the world’s largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale — up to millions of wet lab experiments weekly — and massive computational scale — owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Toronto, Montréal, New York, London, Oxford area, and the San Francisco Bay area. Learn more at www.Recursion.com, or connect on LinkedIn.

Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation.

Accommodations are available on request for candidates taking part in all aspects of the selection process.

Equal Opportunity Employment Information

We are committed to a high-performing workplace where everyone feels like they belong and can do the best work of their careers. We invite you to self-identify your race/ethnicity and gender. This information will be kept confidential and will not be used to favor or discriminate against any candidate. It will not be shared with the hiring managers or otherwise considered as part of your application. Submission of this information is voluntary and refusal to provide any or all of the information requested will not subject you to any adverse treatment.

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