M/F Researcher in biochemistry and/or structural biology

CNRS; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

A leading research organization in France seeks a researcher specializing in enzyme studies to contribute to the ANR ECLECTYC project. The role involves developing microbiological and biochemical techniques for protein production and purification, particularly using non-canonical amino acids. Candidates should have knowledge of biophysical methods and proficiency in scientific English. The position is full-time and located in Marseille.

Qualifications

• Proven ability to perform protein production and purification.
• Experience with EPR spectroscopy is advantageous.
• Strong background in biology and biochemistry.

Responsabilités

• Develop approaches in microbiology and biochemistry.
• Produce and purify proteins with non-canonical amino acids.
• Conduct spectroscopic and biophysical studies.

Connaissances

Knowledge of proteins

Biophysical methods

Experimental work on biological samples

Data analysis

Proficiency in scientific English

Outils

UV-visible spectrometers

EPR spectroscopy

Description du poste

Organisation/Company CNRS Department Bioénergétique et ingénierie des protéines Research Field Chemistry » Biochemistry Physics » Biophysics Biological sciences » Biological engineering Researcher Profile Recognised Researcher (R2) Country France Application Deadline 11 Dec 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 2 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Recruitment is part of the ANR ECLECTYC research contract, which focuses on studying conformational changes in enzymes of the multicopper oxidase family, particularly CueO. The successful candidate will develop approaches in microbiology, biochemistry, spin labeling, and EPR spectroscopy. The objectives will be to produce and purify proteins of interest containing one or two non-canonical amino acids (aanc), to label these proteins using specific paramagnetic probes, and to study their dynamics and conformational changes in the presence of copper in particular.

Keywords: non-canonical amino acids, paramagnetic probes, spin labeling, EPR

• Production and purification of proteins containing ncaa
• Labeling of proteins using paramagnetic probes
• Spectroscopic (RPE, UV-vis, etc.) and biophysical studies
• Protein-protein interactions
• Data analysis
• Writing reports, oral presentations, writing articles

Integration into the «Biophysics of Metalloproteins and Dynamic Systems» team (https://bip.cnrs.fr/groups/bip07/), under the supervision of Marlène Martinho, within the Bioenergetics and Protein Engineering (BIP) laboratory in Marseille on the CNRS Joseph Aiguier campus. Full‑time position in accordance with the internal regulations of the unit and laboratories involved in the collaboration. Computer workstation equipped with the necessary software for the work. Wet bench and laboratory equipment for protein production/purification and biological sample preparation. UV-visible spectrometers, CD, etc. RPE platform specializing in life sciences.

Research Field Biological sciences » Biological engineering Years of Research Experience 1 - 4

Additional Information

Eligibility criteria

Knowledge: knowledge of proteins, biophysical methods applied to proteins. Knowledge of biology and biochemistry. Proficiency in scientific English. Skills: experimental work on biological samples; experience in recording continuous wave EPR spectra would be an advantage; data analysis. Attitudes: ability to work/communicate in a multidisciplinary environment (physics, chemistry, biology), teamwork.