Homéostasie du tissu ovarien : Etude du mécanisme moléculaire de la dormance folliculaire de la[...]

Université Clermont Auvergne; France; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

Une grande université française recherche un candidat pour un contrat doctoral axé sur l'étude de l'oogenèse et la compréhension des mécanismes de dormance des follicules. Le rôle impliquera des recherches approfondies en biologie, en utilisant des tissus ovariens humains pour explorer les mécanismes de dormance. La date de début est prévue pour le 01/10/2025.

Qualifications

• Diplôme de Master ou équivalent dans le domaine lié aux sciences biologiques.
• Connaissances en biologie cellulaire et oogenèse.

Responsabilités

• Étudier le contrôle de l'expression d'un facteur paracrine.
• Confirmer l'impact de ce facteur sur la dormance des follicules.
• Définir la voie de signalisation expliquant la dormance.

Formation

Master en biologie

Connaissances en oogenèse

Description du poste

Overview

Organisation/Company Université Clermont Auvergne

Research Field Biological sciences > Biology

Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3)

Country France

Application Deadline 21 Jun 2205 - 22:00 (UTC)

Type of Contract Temporary

Job Status Full-time

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Mammalian oogenesis represents one of the most spectacular examples of homeostatic control in the living world. After the definition of a large stock of primordial follicles early in development, these can be kept dormant for decades while a few escape this dormancy to enter the steroid phase to generate only one mature oocyte per cycle.

The mechanisms leading to this dormancy and its escape remain poorly understood. Drosophila is considered to have a different strategy with the continuous production of many follicles. However, we have defined physiological conditions under which females accumulate the mature steroid stages. This accumulation causes early follicle dormancy similar to mammals. We have identified a paracrine factor produced by the mature stages and which would inhibit the growth of the young stages. The purpose of this thesis will therefore be to study: 1) the control of the expression of this factor 2) to confirm its impact on follicle dormancy 3) to define the signaling pathway explaining dormancy. Moreover, this factor is conserved in mammals where it is also expressed in follicular cells of mature stages. We will have access, thanks to a local collaboration, to human ovarian tissue containing primordial follicles which will be cultured in the absence or presence of this factor, to test the functional conservation of this factor and of the mechanism of dormancy.

Début de la thèse : 01/10/2025

Funding category: Contrat doctoral

Concours pour un contrat doctoral