2018/02/22 – Postdoctoral position: « Organic chemistry and radiochemistry » (1 year)

France Life Imaging; Saclay, Orsay; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Un laboratoire à Saclay propose un poste de chercheur postdoctoral en chimie organique et radiochimie. Le candidat travaillera sur la synthèse d'agents d'imagerie duales pour une approche theranostique innovante, alliant imagerie par PET et NIRF afin d'améliorer le diagnostic et le soin des patients. Ce poste nécessite un doctorat en chimie organique et une forte expérience en synthèse.

Qualifications

• PhD requis en chimie organique avec un solide bagage en synthèse organique.
• Une expérience en synthèse de colorants fluorescents ou chimie macrocyclique est appréciée.

Responsabilités

• Synthétiser des sondes d'imagerie duales PET/NIRF portant un atome de fluor-18.
• Fonctionnaliser des structures à base de bambusuril avec des entités de ciblage in vivo.

Connaissances

Synthèse organique

Chimie macrocyclique

Synthèse de colorants fluorescents

Formation

PhD en chimie organique

Description du poste

Type de structure : The IMIV laboratory (Imagerie Moléculaire In Vivo) located at the Service Hospitalier Frédéric Joliot (Orsay, France) is a multidisciplinary infra-structure gathering all activities from organic chemistry to clinical trials including preclinical imaging and signal quantification. The laboratory is fully equipped for radiochemistry with positrons emitters such as fluorine-18, carbon-11 and zirconium-89.
The Service de Chimie Bioorganique et de Marquage (SCBM located at Saclay, CEA) conducts methodological research in organic, bioorganic and macrocyclic chemistry, develops targeted drugs and inhibitors in collaboration with biologists.
The work of the postdoctoral fellow will be shared between these two laboratories (IMIV and SCBM) that are only distant of a few kilometers.

Contexte et mission : Applicants are invited to apply for a postdoctoral researcher position in organic chemistry and radiochemistry funded by the Agence Nationale de la Recherche (ANR).
Combined [18F]PET/NIRF imaging (Positron Emission Tomography/Near Infra Red Fluorescence) hold a huge potential to transform patient diagnosis and care. Such a combination conjugates the non-invasive whole-body diagnosis of PET with the intraoperative imaging-guided surgery or ex vivo histopathology of NIRF imaging. To implement this highly valuable dual imaging theranostic approach, adapted and smart imaging tools have to be developed. In the frame of the M3ODALIty project funded by the Agence Nationale de la Recherche (ANR), new monomolecular, multivalent and multiplexed PET/NIRF imaging agents will be synthesized.
The objectives are:
- To synthesize a series of dual PET/NIRF probes bearing a fluorine-18 atom,
- To functionalize bambusuril-based scaffolds with in vivo targeting entities and the dual imaging dye to build new imaging agents that can be used in combined PET and NIRF imaging.
The laboratories involved in M3ODALIty are located at the CEA-Saclay and Orsay (around 20 km south of Paris).
Availability:
June/September 2018,

Lieu : IMIV (CEA-SHFJ, Orsay) and SCBM (CEA, Saclay) (around 20 km south of Paris)

Diplômes requis : PhD in organic chemistry with a strong organic synthesis background

Compétences requises : Experience in fluorescent dye synthesis or macrocyclic chemistry would be appreciated.

Contact : Applicants are invited to send a CV, cover-letter, list of publications and references to: Bertrand Kuhnast, [e-mail] and Marie Pierre Heck, [e-mail]