Postdoctoral Researcher - Industrial Biotechnology / Metabolic Engineering of Clostridia

Fraunhofer-Gesellschaft; Aachen; Vor Ort; EUR 60.000 - 80.000; Vollzeit

Zusammenfassung

Ein führendes Forschungsinstitut in Aachen sucht einen hochmotivierten Postdoktoranden im Bereich angewandte Biotechnologie. Der ideale Kandidat hat einen PhD in Biotechnologie oder einem verwandten Bereich und Erfahrungen mit Clostridia. Die Aufgaben umfassen die Entwicklung von Fermentationsprozessen und metabolischer Ingenieurskunst in einem innovativen, interdisziplinären Umfeld. Das Institut bietet eine inspirierende Forschungsatmosphäre, Zugang zu modernen Laboreinrichtungen und eine Vergütung von bis zu 6.800 € brutto monatlich.

Leistungen

Zugang zu modernen Laboreinrichtungen

Möglichkeiten zur beruflichen Weiterentwicklung

Qualifikationen

• PhD in einem relevanten Gebiet.
• Erfahrung in der Arbeit mit Clostridia ist von Vorteil.
• Starke praktische Fähigkeiten in Molekularbiologie und Genetik.

Aufgaben

• Klone und entwickle Expressionssysteme.
• Führe metabolische Fluxanalysen durch.
• Entwickle kontinuierliche Fermentationsprozesse unter anaeroben Bedingungen.

Kenntnisse

Molekularbiologie

Genetik

Metabolische Ingenieurskunst

Erfahrung mit strengen Anaerobier

Teamarbeit

Ausbildung

PhD in Biotechnologie, Mikrobiologie oder Molekularbiologie

Jobbeschreibung

The Fraunhofer Institute for Molecular Biology and Applied Ecology IME conducts applied life sciences from the molecule to the ecosystem. It is our vision to pave the way to a sustainable future through applied life sciences.

TheIndustrial Biotechnology Department, headed by Dr. Stefan Jennewein, at the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) in Aachen, is looking for a highly motivated postdoctoral researcher to join our team in ongoing and future projects on syngas fermentation with Clostridia. Our research focuses on Clostridium carboxidivorans and Clostridium ljungdahlii, for which we have already established robust genetic and process engineering platforms. The following publications illustrate the potential and direction of our work:

• Lauer et al. (2022): Metabolic engineering of Clostridium ljungdahlii for the sustainable production of hexanol and butanol from CO ₂ and H ₂, Microb. Cell Fact. 21:85
• Kottenhahn et al. (2021): Hexanol biosynthesis from syngas by Clostridium carboxidivorans P7 is enhanced by in-line extraction with a biocompatible solvent to avoid product toxicity, Heliyon 7:e07732
• Philipps et al. (2019): Development of a metabolic pathway transfer and genomic integration system for the syngas-fermenting bacterium Clostridium ljungdahlii, Biotechnol. Biofuels 12:112

What you will do

• Cloning and construction of expression systems
• Metabolic flux analysis for pathway characterization and optimization
• Development and operation of continuous fermentation processes under strict anaerobic conditions
• Strategic contribution to platform development for metabolic engineering

What you bring to the table

• PhD in biotechnology, microbiology, molecular biology, or a related field
• Experience working with strict anaerobes, ideally with Clostridia
• Strong hands-on skills in molecular biology and genetic engineering of microorganisms
• Interest in applied research at the interface of synthetic biology, systems biology, and process development
• Independent, solution-oriented work ethic and strong team spirit
• German language skills are not required; working language can be English

What you can expect

• A vibrant and innovative research environment at one of Europe’s leading applied research organizations
• Participation in interdisciplinary projects on sustainable bioconversion of syngas and CO₂
• Access to modern laboratories, including fully equipped anaerobic workstations and continuous bioreactor systems
• A collaborative team atmosphere with flat hierarchies
• Opportunities for professional and personal development

Remunerationup toTVöD pay group 13, with a maximum monthly gross amount of 6,800 euros (dependent on qualifications).

The weekly working time is 39 hours. We value and promote the diversity of our employees' skills and therefore welcome all applications - regardless of age, gender, nationality, ethnic and social origin, religion, ideology, disability, sexual orientation and identity. Severely disabled persons are given preference in the event of equal suitability.

With its focus on developing key technologies that are vital for the future and enabling the commercial utilization of this work by business and industry, Fraunhofer plays a central role in the innovation process. As a pioneer and catalyst for groundbreaking developments and scientific excellence, Fraunhofer helps shape society now and in the future.

Interested? Apply online now. We look forward to getting to know you!

For questions regarding the position, please contact:
Dr. Stefan Jennewein
Head of Industrial Biotechnology Department
Fraunhofer IME, Aachen
E-Mail: [e-mail]

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Division Molecular Biotechnology

www.ime.fraunhofer.de

Requisition Number: 80353