Postdoc (f/m/x) - Analyzing the effectiveness and safety of a novel RNA delivery platform

Helmholtz Zentrum München; Oberschleißheim; Vor Ort; EUR 50.000 - 70.000; Vollzeit

Zusammenfassung

A leading biomedical research institute in Germany is seeking a Postdoc to evaluate an innovative RNA delivery platform. The ideal candidate will have a PhD in Life Sciences and a strong publication background, focusing on animal model efficacy and molecular applications. Responsibilities include testing therapeutic cargos and authoring scientific work. This position offers a fixed term of 2.5 years, competitive benefits, and a collaborative research environment.

Leistungen

Career Development programs

30 days annual leave

Health Promotion initiatives

International Staff Service

State-of-the-art infrastructure

Qualifikationen

• PhD degree in Biology or related field.
• Strong publication record; at least one first-author paper preferred.
• Experience handling and analyzing animal models.
• Qualifications for working with mice.
• Hands-on experience in analytical techniques.
• Familiarity with delivery vehicles.

Aufgaben

• Test efficacy of STV-delivered therapeutic cargos.
• Characterize immunological and cellular responses.
• Write manuscripts and draft illustrations.
• Contribute to patent applications.
• Supervise students if desired.

Kenntnisse

PhD in Biology / Life Sciences / Biotechnology / Biochemistry

Excellent publication record

Experience with animal models

Analytical techniques experience

Genetically encoded delivery vehicles experience

Strong communication skills in English

Ausbildung

PhD degree

Tools

Biochemical assays

Advanced imaging technologies

Jobbeschreibung

Postdoc (f/m/x) – Analyzing the effectiveness and safety of a novel RNA delivery platform

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real‑life applications, improving lives.

Recently, our Gene Editing group at the Institute of Stem Cell Research developed Synthetic Transfer Vehicles (STVs), a programmable protein‑based RNA delivery platform that packages defined RNA cargos and delivers them to specific cell types. STVs consist of a synthetic protein that is assembled from natural and AI‑designed protein domains, along with an engineered fusogenic protein. The technology has been recognized with the 4th Award, the GO‑Bio next program, and is currently under revision in a top‑tier journal (preprint: 10.21203/rs.3.rs-5123765/v1).

We now aim to translate this platform by delivering gene editing tools, mRNA therapeutics, and other functional cargos into disease models. To drive this effort, we are seeking a highly motivated postdoctoral researcher (f/m/x) with a strong interest in advancing molecular technologies toward clinical application.

Your tasks

• Testing the efficacy of STV‑delivered therapeutic cargos in animal models
• Characterizing immunological, cellular, and molecular responses to different cargo RNAs in animal models
• Writing manuscripts and drafting scientific illustrations
• Contributing to patent applications
• Supervising students (if desired)

Your profile

Your Scientific Qualifications

• PhD degree in Biology / Life Sciences / Biotechnology / Biochemistry or related fields
• Excellent publication record, preferably with at least one first‑author publication
• Extensive experience with handling and analyzing animal models
• Valid qualifications and certifications for working with mice
• Hands‑on experience in analytical techniques (e.g., biochemical assays, advanced imaging technologies, immunological and toxicological assays)
• Experience with genetically encoded delivery vehicles

Your Personal Qualifications

• Enthusiasm for applying molecular tools to solve biomedical needs
• Drive to work toward highly ambitious scientific goals, passion for innovating at the interface of research and clinical translation
• Willingness and ability to convert scientific work into high‑impact publications and patents
• Commitment to working in a fast‑moving and highly competitive field as well as in a dynamic and highly collaborative group
• Excellent written and spoken communication skills in English

If you fulfill all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public‑Sector Employees (TVöD). This position is for a fixed term of 2.5 years.

Benefits

• Career Development: Postdoc program, scientific training & career center with tailored offers
• Scientific Resources: State‑of‑the‑art infrastructure and Core Facilities
• Recreation: 30 days annual leave, flexi days, plus public holidays
• International Staff Service: Support with the relocation and integration process in Germany
• Health Promotion: Sports, company doctor, mental health initiatives

Interested in applying?

For questions, contact Florian Giesert ([e-mail]).

Our recruiting is decentralized – your application will be reviewed directly by the specialist department in which you could work in the future.

Please send your application only via our online application tool and with the following documents:

• CV
• Cover letter
• Degrees/Diplomas/Certificates
• Contact details for at least two referees

If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.

Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Stem Cell Research
Ingolstädter Landstraße 1
85764 Neuherberg

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