Research Scientist/Senior Scientist, Downstream Processing (BTI)

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A leading research organization in Singapore seeks a lead scientist to develop purification processes and analytics for biotherapeutics. The ideal candidate will hold a PhD and possess extensive experience with chromatography and separation techniques. Responsibilities include leading research teams, designing experiments, and publishing scientific findings. This is an exciting opportunity to contribute to innovative R&D projects in a dynamic environment.

Qualifications

• PhD with relevant experience in purification and analytics for biotherapeutics.
• Proficient in preparing chromatography and other separation techniques.
• Hands-on experience in purification processes.

Responsibilities

• Lead scientist for purification process and analytics.
• Design and execute relevant experiments.
• Analyze data and plan subsequent steps.
• Supervise research officers and manage projects.

Skills

Analytical skills

Scientific writing

Communication skills

Education

PhD Degree in biochemical engineering, biochemistry, or related field

Tools

Affinity chromatography

HPLC

ELISA

PCR

Western-blot

Job description

JOB DESCRIPTION

Successful candidate will work within a R&D team developing purification process and analytics for biotherapeutics production. Main responsibilities include:

• Be able to work as a lead scientist for the development of purification process and analytics for the production of a variety of emerging biotherapeutics, such as bispecific and multi‑specific antibodies, vaccines, viral vectors and nucleic acid therapies.
• Be able to lead a few research officers to work on different industrial collaboration projects and in‑house projects.
• Design and execute experiments based on proposed project scopes.
• Routinely run purification systems and crossflow systems for biotherapeutics purification and handle a range of analytical equipment for biotherapeutics characterization.
• Analyze data, interpret results and plan the next step.
• Regularly update project progress in internal and external project meetings and prepare project reports.
• Be capable at scientific writing, including scientific publication and grant application proposal.
• Perform general lab housekeeping and other administrative tasks.

JOB REQUIREMENT

• A PhD Degree in biochemical engineering, biochemistry, protein engineering or a related field with commensurate experience.
• Broad experience with preparative chromatography, including affinity, ion exchange, hydrophobic interaction, size exclusion, etc.
• Broad experience with other separation techniques, including clarification, filtration, precipitation, etc.
• Broad experience with bioassay and analytical technology, including ELISA, HPLC, PCR, SDS‑PAGE, western‑blot, DLS, etc.
• Hands‑on experience with purification of biotherapeutics using protein purification system.
• Excellent analytical, writing and communication skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.