Senior / Principal Scientist

Michael Page; England; Hybrid; GBP 35,000 - 60,000; Full time

Job summary

A leading biotech company is seeking a skilled scientist to join their team focusing on cutting-edge TCR-based therapies. The successful applicant will lead in vivo and in vitro validation efforts, collaborate on TCR designs, and engage in essential protein science tasks. A supportive, cross-disciplinary team and a competitive salary offer await the right candidate, along with market-competitive benefits.

Benefits

Market-competitive salary and stock options

25 days holiday plus public holidays and a birthday leave

Access to a fully equipped private lab

Work from home flexibility as project demands allow

Qualifications

• 1-2 years of relevant lab experience required; for senior role, over 3 years industry experience.
• Experience in T-cell engager validation and molecular biology protocols preferred.
• Desired experience in cell and immunological assays.

Responsibilities

• Lead in vivo and in vitro validation of TCEs.
• Design and characterise TCRs for disease targets.
• Conduct protein science operations including expression and purification.

Skills

Molecular Biology

Protein Expression

Purification

Biophysical Analysis

Flow Cytometry

ELISA

NGS Analysis

SOP Documentation

Education

PhD in Immunology, Cell Biology, Biochemistry or alike

Job description

• A fantastic opportunity to join a growing biotech
• Working on development of novel TCR-based therapies

About Our Client

The client are reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies.

Job Description

• Lead in vivo and in vitro validation of TCEs.
• Collaboratively design and characterise TCRs for proprietary and partnered disease targets.
• Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.
• Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.
• Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.
• Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.
• Draft, revise, and oversee repertoire of lab protocols.
• Offer essential lab support and uphold facility upkeep

The Successful Applicant

• PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.
• For senior scientist we are looking for over 3 years industry experience.
• Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to investigational new drug (IND) approval is critical Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred.
• A background in protein expression, purification and biophysical characterisation is preferred.
• Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.
• Experience in NGS analysis pipeline (specifically data analysis using software such as R) is desired.
• SOP documentation experience is desired.

What's on Offer

• Market-competitive salary and stock option package.
• A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday!
• Access to fully equipped private lab.
• Flexibility to work from home as project demands allow.
• A supportive, cross-disciplinary team fostering a highly collaborative work environment.