Research Scientist - Affinity Reagents

AstraZeneca; Cambridge; On-site; GBP 30,000 - 55,000; Full time

Job summary

A leading biopharmaceutical company in Cambridge is seeking a motivated scientist to enhance antibody development workflows and validate antibodies. The ideal candidate will have a strong background in cell biology and immunoassays, with proficiency in various antibody applications. Join a collaborative environment where your contributions can impact drug discovery significantly. This role requires a BSc/MSc in a relevant field and offers a chance to grow in an innovative setting.

Qualifications

• Significant lab-based experience in biological sciences.
• Experience in antibody generation strategies.
• Ability to troubleshoot and deliver projects with clear reporting.

Responsibilities

• Enhance antibody development workflows.
• Validate antibodies through relevant assays.
• Deliver robust data for project decisions.

Skills

Mammalian cell culture

Construct design & overexpression

Transfection

Cloning

RT-PCR

Antibody applications (ELISA/HTRF)

Western blotting

Flow cytometry

Immunofluorescence

Immunoprecipitation

Education

BSc/MSc in biology or related discipline

Job description

Are you passionate about cell biology and immunoassays, with a keen interest in antibody development and validation? At AstraZeneca, you'll have the chance to deliver high-quality antibodies that drive discovery across diverse therapeutic areas. Join us in a collaborative and innovative environment where your contributions directly influence decision-making in drug projects.

Accountabilities

We are looking for a motivated scientist to enhance antibody development workflows and play a pivotal role in validating antibodies through end-use relevant assays. Your work will ensure robust, reproducible data for project decisions. You will execute skilled cell biology workflows and immunoassays, coordinate with stakeholders, and deliver activities crucial for drug discovery. Additionally, you will manage the team's antibody assets and support data management.

Essential Skills / Experience

• BSc/MSc (or equivalent) in biology, cell biology, or related discipline; significant lab-based experience
• Strong skills in mammalian cell culture, construct design & overexpression, transfection, KD/KO (CRISPR/siRNA), cloning, RT-PCR
• Proficiency in a range of antibody applications: ELISA/HTRF, western blotting, flow cytometry, immunofluorescence, immunoprecipitation
• Solid understanding of the challenges and approaches to antibody validation, ideally with specific, demonstrable experience
• Experience or strong theoretical knowledge of antibody generation strategies and antibody/affinity binder development methodologies
• Evidence of high level of organisation, and strong collaborative working style
• Ability to troubleshoot and deliver to projects to completion, with clear reporting
• Documented proficiency in English (written and spoken)

Desirable Skills / Experience

• Immunohistochemistry (IHC) experience or theoretical knowledge
• NGS experience, such as library preparation
• Familiarity or experience with protein expression/purification & QC methods
• Use of automation, such as liquid handling
• Project coordination (SOPs, timelines, CRO interactions, data management)

At AstraZeneca, we are driven by our passion for science and the potential it holds to transform healthcare. We are committed to making a difference by fusing data and technology with scientific innovation to achieve breakthroughs. Our inclusive environment encourages curiosity and courage, empowering you to explore without limits and make bold decisions. Collaborating with academia, biotechs, and industry partners, we leverage diverse knowledge to create impactful solutions for complex diseases. Here, lifelong learning is embraced as we push the boundaries of science to deliver life-changing medicines.

Ready to make an impact? Apply now and join us in shaping the future of healthcare!

Date Posted: 12-nov.-2025

Closing Date: 26-nov.-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.