Principal/Senior Scientist Director, head of Safety Pharmacology & Early Toxicology Director Is[...]

Novo Nordisk A/S; Oxford; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading global healthcare company seeks a Research Scientist to design and optimize in-vitro functional genomics workflows for metabolic diseases. Responsibilities include gene editing, executing high-throughput screens, and analyzing data. Candidates must hold a PhD or master's with relevant experience and have practical skills in assay development and gene editing. This role is crucial for advancing disease treatment and involves collaboration within interdisciplinary teams. The position is located in Oxford and offers a unique environment aimed at serious disease solutions.

Qualifications

• Practical experience in executing medium-to-high-throughput functional genomics or cell-based screens.
• Experience with gene editing techniques.
• Ability to analyze experimental data independently with statistical approaches.

Responsibilities

• Engineer cell lines and perform gene editing for assay development.
• Execute functional genomics screens using state-of-the-art methods.
• Analyze screening data using established quality metrics.

Skills

Assay development

Gene editing

Statistical analysis

Automation platforms

Problem-solving

Communication

Education

PhD or master's degree in Molecular Biology, Biochemistry, Cell Biology or related field

Tools

ELN

Job description

As a Research Scientist you will design, execute and optimise in‑vitro functional genomics and cell‑based screening workflows that enable target discovery in metabolic diseases such as diabetes and obesity. You will deliver high quality experimental data, adopt and validate automation and digital tools, and translate screening results into concise insights that drive target progression into the NN pipeline. This role is a maternity leave cover. Day‑to‑day your tasks will include:

Responsibilities

• Engineer cell lines and perform gene editing to develop and validate cell‑based assays for functional genomics and screening.
• Execute medium‑to‑high‑throughput functional genomics screens using state‑of‑the‑art perturbation methods and quantify disease‑relevant functional or phenotypic responses in complex human in‑vitro models.
• Apply Design of Experiment (DoE) principles to accelerate assay development and adapt workflows based on real‑time data to optimise performance.
• Operate, maintain and troubleshoot automated and semi‑automated equipment and consistently document experiments in ELNs and relevant databases.
• Independently analyse screening data using established quality metrics and digital tools, producing concise summaries to inform target selection.
• Collaborate with internal and external stakeholders to progress projects, support partnerships and contribute to the timely reporting and publication of results.

About the Team & Culture

You will join Functional Genomics Group within In Vitro Science department in UK and work closely with Target Discovery and Technology Leaders teams and across departments with expertise in several scientific disciplines. Our interdisciplinary teams combine experimental biology, automation and digital biology approaches to accelerate the identification and validation of targets for the NN pipeline. Every day we seek the solutions that defeat serious chronic diseases. Here you'll join an innovative, collaborative environment that values curiosity and scientific rigour while supporting development and cross‑functional learning. Your work will contribute directly to target selection and pipeline decisions that can lead to meaningful patient impact.

Qualifications

• Hold a PhD or master's degree (with 3–5 years of relevant experience) in Molecular Biology, Biochemistry, Cell Biology or a related field.
• Have practical experience in assay development and execution of medium‑to‑high‑throughput in‑vitro functional genomics or cell‑based screens.
• Have experience in gene editing and cell engineering techniques and competent using automation or semi‑automation platforms.
• Be able to analyse experimental data independently using appropriate statistical approaches and digital tools; familiar with FAIR data principles and ELN usage.
• Demonstrate strong problem‑solving skills, ability to troubleshoot complex assays and implement improvements with minimal guidance.
• Communicate project work and results clearly to cross‑functional teams and contribute constructively to scientific discussions.

Title Note & Equality Statement

Novo Nordisk is currently in the process of adjusting job titles globally. Please note that the job title listed in this advertisement may be subject to change. More detailed information will be provided during the recruitment process.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. We're not your typical healthcare company. In a modern world of quick fixes, we focus on solutions to defeat serious chronic diseases and promote long‑term health. Our unordinary mindset is at the heart of everything we do. We seek out new ideas and put people first as we push the boundaries of science, make healthcare more accessible, and treat, prevent, and even cure diseases that affect millions of lives. Because it takes an unordinary approach to drive real, lasting change in health.