PDRA (Post Doctoral Research Assistant) (Redeployment List Candidates Only)

City University London; City Of London; On-site; GBP 36,000 - 44,000; Full time

Job summary

A leading university in the UK is seeking a Post Doctoral Research Assistant to develop an innovative method for extracting Mycobacterium tuberculosis DNA from clinical samples. Candidates should possess a BSc and PhD in biomedical sciences, along with expertise in molecular cloning and CL2/CL3 handling. This fixed-term, full-time position is ideal for those with a passion for molecular diagnostics and bacteriophage technology.

Benefits

Sector-leading salary

Pension scheme

Comprehensive staff training and development

Qualifications

• BSc and PhD in biomedical sciences or closely related subject.
• Knowledge of CL2/CL3 handling, cloning, recombinant protein purification.
• Experience with molecular cloning and working with bacteriophages preferred.

Responsibilities

• Develop a lysis solution for DNA extraction from Mycobacterium tuberculosis.
• Assess robustness and sensitivity of lysis solution across sample types.
• Maximise sensitivity through enrichment of Mtb bacilli.

Skills

Knowledge of CL2/CL3 handling

Molecular cloning

Bacteriophage manipulation

Recombinant protein purification

Education

BSc and PhD in biomedical sciences or closely related subject

Job description

PDRA (Post Doctoral Research Assistant) (Redeployment List Candidates Only)

Location: Tooting Campus, City St George's, University of London

Contract Type: Fixed‑term, Full‑time

Salary: £43,482

Closing Date: 07 December 2025 at 11:59 pm

Overview

We are seeking a redeployed postdoctoral researcher to develop a novel, inexpensive method for extracting Mycobacterium tuberculosis DNA from clinical samples without mechanical equipment. The project will involve CL2/CL3 pathogen handling, molecular cloning, and bacteriophage manipulation.

Main Activities

• Develop a lysis solution using pore‑forming short cationic peptides and a mycobacteriophage that disrupts both host and Mycobacterium cell membranes, enabling DNA release into a buffer compatible with downstream NAAT processing.
• Assess the robustness and sensitivity of the lysis solution across sample types (tongue swabs, exhaled breath condensate, sputum) using quantitative microbiological methods.
• Maximise sensitivity through enrichment of Mtb bacilli by adding a mycobacteriophage capture step before lysis and exploring various lytic agents.

Key Attributes of the Successful Applicant

• BSc and PhD in biomedical sciences or closely related subject.
• Knowledge of CL2/CL3 handling, cloning, recombinant protein purification, bacteriophage biology, and molecular diagnostics.
• Experience with molecular cloning and working with bacteriophages preferred.

Important: This role is only open to redeployed City St George's employees; applications from outside candidates will not be considered.

Application Process

Please quote reference 673‑25 and the job title in your email. Send your CV and cover letter to [e-mail], demonstrating how you meet the essential criteria outlined above.

Equality, Diversity and Inclusion

City St George’s University of London is committed to promoting equality, diversity and inclusion. We welcome applications regardless of age, caring responsibilities, disability, gender identity, marital status, nationality, pregnancy, race and ethnic origin, religion and belief, sex, sexual orientation and socio‑economic background. We operate a guaranteed interview scheme for disabled applicants.

Working Arrangement

Relevant professional services roles may be undertaken in a hybrid manner, with the expectation that at least 60% of working time will be on campus. Specific details will be discussed with the successful candidate.

City St George's offers a sector‑leading salary, pension scheme, and benefits including a comprehensive package of staff training and development.