Senior Scientist, Computational Biology @Brink Therapeutics

Nabla; Paris; Sur place; EUR 70 000 - 100 000; Plein temps

Résumé du poste

A pioneering biotech company in Paris is looking for a Senior Scientist in Computational Biology to innovate and develop computational pipelines. You'll collaborate with the Molecular Biology and AI teams and manage complex workloads while supporting the development of gene therapy tools. The ideal candidate will have a strong background in bioinformatics, including software development and project management skills, and a desire to work in a fast-paced startup environment.

Prestations

Competitive salary

Benefits package

Well-equipped offices & labs

Qualifications

• Experience in computational biology or related fields.
• Proven record of solving complex problems independently.
• Experience in startup environments is a plus.

Responsabilités

• Develop and execute processes for enzyme variant libraries.
• Design computational pipelines for NGS data.
• Analyze human -omics datasets for therapeutic insights.
• Mentor junior team members.

Connaissances

Bioinformatics expertise

Software development

Project management

Problem-solving skills

Communication skills

English proficiency

Formation

MSc with 5+ years of experience or PhD with 2+ years in Computational Biology

Outils

Python

GitHub

AWS

Description du poste

Senior Scientist, Computational Biology @ Brink Therapeutics

Brink Therapeutics is a venture-backed biotech company specializing in gene therapy tools based on site‑specific recombinases, offering safer alternatives to CRISPR‑Cas9. As one of the first team members, you'll join the development of advanced directed evolution, gene‑mining, and AI‑driven pipelines to treat cancers, autoimmune diseases, and genetic disorders.

Mission Highlights

As a Senior Scientist in Computational Biology, you will innovate and develop computational pipelines in collaboration with Molecular Biology and AI teams. Your goals include supporting the wet‑lab team in generating lead recombinase candidates and generating massive functional datasets for AI mining.

Responsibilities

• Develop & execute processes for the design of ultra‑large, smart enzyme variant libraries.
• Develop & execute computational pipelines for analysis of NGS data from our advanced in vitro recombinase directed evolution platform.
• Develop & execute NGS‑based processes for efficient readout of directed evolution assays.
• Develop & execute pipelines for mining public (meta)genomic datasets for discovery of new gene variants and insights into their properties.
• Analyze human -omics datasets for discovery of sites of therapeutic interest.
• Communicate project status, requirements, risks and mitigation to stakeholders.
• Maintain detailed documentation and present results to stakeholders.
• Disclose innovations to internal stakeholders to secure IP protection.
• Mentor & coach junior team members.

Competencies & Qualifications

You have a broad array of bioinformatics domain expertise and software development skills, are highly organized and enjoy managing complex workloads while clearly documenting and communicating results in an actionable manner to both wet‑lab and computational scientists. You are a sharp, collaborative trouble‑shooter who doesn’t shy away from hard problems and takes joy in working toward ambitious goals as part of a multidisciplinary team.

Required:

• MSc with 5+ years of experience or PhD with 2+ years of experience in computational biology or related fields, and eagerness to keep learning.
• Proven record of innovative and independent problem‑solving skills.
• Demonstrated expertise in computational biology pipeline design and software development (incl. Python, GitHub, AWS).
• Project management experience.
• Excellent written and oral communication.
• English – professional working proficiency.
• Motivation to work in a flexible and fast‑paced startup.

The ideal candidate will also have some of the following:

• Experience working in startup environments.
• Expertise in directed evolution, gene library synthesis, NGS, genome editing, human genomics, computational enzymology, computational structural biology.

Recruitment Process

• Profile review against requirements.
• Introductory call with the CEO (and cofounder) Jonathan Naccache.
• Technical interview with the CTO (and cofounder) Harry Kemble.
• Value‑fit interviews with the rest of the team, on‑site.

Why Join Us?

• Unique opportunity to be part of an early‑stage biotech company shaping genome editing for Cell and Gene Therapy.
• Competitive salary plus benefits package.
• Beautiful, well‑equipped offices & labs in the heart of Paris.

If you're excited about helping revolutionize genome editing and opening up Cell & Gene Therapy to millions who could benefit, apply now and let's make the difference together!