Synthetic Chemist - Peptide Synthesis Specialist

Eurofins Villapharma Research; Murcia; Presencial; EUR 40.000 - 60.000; Jornada completa

Descripción de la vacante

Una empresa farmacéutica internacional busca un Químico Sintético talentoso con experiencia en síntesis de péptidos. Las responsabilidades incluyen diseñar y ejecutar síntesis de fase sólida y optimizar rutas sintéticas. Se requiere un Ph.D. o M.Sc. en química orgánica y de 2 a 5 años de experiencia en un entorno de CRO o farmacéutico. Ofrecemos un entorno de investigación de vanguardia con oportunidades para el crecimiento y la colaboración.

Formación

• Experiencia práctica en síntesis de péptidos en un entorno de CRO o farmacéutico.
• Conocimiento fuerte de estrategias de grupos protectores y selección de resinas.
• Experiencia en química de peptidomiméticos y macrociclación es altamente deseable.

Responsabilidades

• Diseñar y ejecutar síntesis de péptidos en fase sólida con técnicas automáticas y manuales.
• Desarrollar y optimizar rutas sintéticas para péptidos lineales y cíclicos.
• Realizar purificación utilizando HPLC preparativa.

Conocimientos

Sintesis de péptidos

Química orgánica

Habilidades de resolución de problemas

Comunicación efectiva

Educación

Ph.D. o M.Sc. en Química Orgánica

Herramientas

HPLC

Biotage

CEM Liberty Blue

Descripción del empleo

Role Overview

Por favor, asegúrese de leer atentamente los siguientes detalles antes de enviar cualquier solicitud.

We are seeking a talented and detail-oriented Synthetic Chemist with demonstrated hands‑on experience and expertise in peptide synthesis to support our expanding drug discovery programs. The successful candidate will contribute to the design, synthesis, purification, and characterization of peptides and peptidomimetics, working closely with multidisciplinary teams in a dynamic and collaborative environment.

Key Responsibilities

Design and execute solid‑phase peptide synthesis (SPPS) using automated synthesizers and manual techniques.

Develop and optimize synthetic routes for linear and cyclic peptides, including complex modifications and conjugations.

Perform purification using preparative HPLC, SFC, MPLC chromatography, and other relevant techniques.

Characterize compounds using HRMS, NMR, and other analytical tools.

Collaborate with medicinal chemists and biologists to support SAR studies and lead optimization.

Document experimental procedures and results in electronic lab notebooks (ELNs) and contribute to internal reports and publications.

Ensure compliance with Eurofins' quality standards and safety protocols.

Qualifications

Ph.D. or M.Sc. in Organic Chemistry, Medicinal Chemistry, or related discipline.

Minimum 2–5 years of hands‑on experience in peptide synthesis, preferably in a CRO or pharmaceutical setting.

Proficiency with automated peptide synthesizers (e.g., Biotage, CEM Liberty Blue).

Strong understanding of protecting group strategies, coupling reagents, and resin selection.

Experience with peptidomimetics, macrocyclization, or conjugation chemistry is highly desirable.

Experience in parallelization using automated platforms is also highly desirable.

Excellent problem‑solving skills and attention to detail.

Strong communication skills and ability to work effectively in a team‑oriented environment.

Why Join Us

Work in a cutting‑edge research environment with access to state‑of‑the‑art facilities.

Be part of a global scientific network with opportunities for growth and collaboration.

Contribute to impactful drug discovery projects that advance human health.